DegronMD

Uniprot ID: Q5T5P2

Source protein: Sickle tail protein homolog

Source gene: KIAA1217

Class: DEG_SCF_FBW7_1

Location: 1916:1922

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 84.1714

COIL: 0.8417

CONS_SCORE: 0.4273

DSS_SCORE: 0.6292

HELIX: 0.0219

FCONS_SCORE: 1.0798

RIG_SCORE: 0.7129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1915I	TCGA-EE-A29M	SKCM	TCGA	IHTPSLT	DEG_SCF_FBW7_1	0.3056
p.T1915I	DO37404	SKCM	ICGC	IHTPSLT	DEG_SCF_FBW7_1	0.3056
p.G1929R	TCGA-FW-A3R5	SKCM	TCGA	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.G1929R	TCGA-FW-A3TU	SKCM	TCGA	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.G1929R	DO37406	SKCM	ICGC	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.G1929R	DO37441	SKCM	ICGC	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.N1928S	DO23486	LINC	ICGC	IHTPSLT	DEG_SCF_FBW7_1	0.1667
p.T1922A	SIDM00845	Burkitt's Lymphoma	GDSC	IHTPSLT	DEG_SCF_FBW7_1	0.7139
p.G1912S	SIDM00427	Ewing's Sarcoma	GDSC	IHTPSLT	DEG_SCF_FBW7_1	0.2222
p.G1912S	RH-1	soft_tissue	COSMIC	IHTPSLT	DEG_SCF_FBW7_1	0.2222
p.G1909C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.G1909C	ACH-002256	Leukemia	CCLE	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.G1909C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IHTPSLT	DEG_SCF_FBW7_1	0.1389
p.H1917N	SIDM01608	Endometrial Carcinoma	GDSC	IHTPSLT	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5P2	Sickle tail protein homolog	DEG_SCF_FBW7_1	1916:1922	IHTPSLT	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons