DegronMD

Uniprot ID: Q5T5P2

Source protein: Sickle tail protein homolog

Source gene: KIAA1217

Class: DEG_APCC_KENBOX_2

Location: 1241:1245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 115.96

COIL: 0.771

CONS_SCORE: 0.3078

DSS_SCORE: 0.3663

HELIX: 0.185

FCONS_SCORE: 1.1341

RIG_SCORE: 0.7882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1254Y	TCGA-85-6561	LUSC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.0833
p.D1254Y	TCGA-BS-A0UF	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.0833
p.D1254Y	DO26518	LUSC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.0833
p.D1254Y	DO41488	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.0833
p.R1231I	TCGA-A5-A0G2	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.0556
p.R1231I	TCGA-D1-A17Q	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.0556
p.R1231I	DO41903	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.0556
p.R1231I	DO41235	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.0556
p.E1238K	SIDM00299	Other Sarcomas	GDSC	MKENS	DEG_APCC_KENBOX_2	0.25
p.E1238K	ACH-002271	Sarcoma	CCLE	MKENS	DEG_APCC_KENBOX_2	0.25
p.E1238K	MFH-ino	soft_tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.25
p.E1243D	SIDM01588	Endometrial Carcinoma	GDSC	MKENS	DEG_APCC_KENBOX_2	0.6758
p.E1243D	ACH-000993	Endometrial/Uterine Cancer	CCLE	MKENS	DEG_APCC_KENBOX_2	0.6758
p.L1236F	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.3056
p.D1252Y	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.1389
p.S1240L	ME-180	cervix	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.3056
p.P1232L	Mewo	skin	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.0833
p.G1233S	RH-1	soft_tissue	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.1111
p.A1255S	TMK-1	stomach	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.0556
p.A1255S	HuO9	bone	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.0556
p.S1237L	HT-115	large_intestine	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons