DegronMD

Uniprot ID: Q8TEQ6

Source protein: Gem-associated protein 5

Source gene: GEMIN5

Class: DEG_APCC_KENBOX_2

Location: 766:770

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8707

ASA_SCORE: 84.04

COIL: 0.5658

CONS_SCORE: 0.5063

DSS_SCORE: 0.7319

HELIX: 0.0198

FCONS_SCORE: 1.0453

RIG_SCORE: 0.5778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S757L	TCGA-AX-A0J0	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	TCGA-AX-A2HC	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	TCGA-B5-A0JY	UCEC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	TCGA-YG-AA3N	SKCM	TCGA	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	DO51298	SKCM	ICGC	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	DO43041	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	DO41572	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.5278
p.S757L	DO41133	UCEC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.5278
p.E774Q	TCGA-DQ-5624	HNSC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.2222
p.E774Q	DO14158	HNSC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.2222
p.N775D	TCGA-UB-A7MB	LIHC	TCGA	MKENS	DEG_APCC_KENBOX_2	0.1944
p.N775D	DO52318	LIHC	ICGC	MKENS	DEG_APCC_KENBOX_2	0.1944
p.I758M	DO222737	COCA	ICGC	MKENS	DEG_APCC_KENBOX_2	0.1111
p.G776S	DO46751	PAEN	ICGC	MKENS	DEG_APCC_KENBOX_2	0.1667
p.E763Q	SIDM02042	Pancreatic Carcinoma	GDSC	MKENS	DEG_APCC_KENBOX_2	0.25
p.S765N	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	MKENS	DEG_APCC_KENBOX_2	0.75
p.S765N	ACH-000904	Lung Cancer	CCLE	MKENS	DEG_APCC_KENBOX_2	0.75
p.S765N	ACH-001362	Lung Cancer	CCLE	MKENS	DEG_APCC_KENBOX_2	0.75
p.S765N	NCI-H1770	lung	COSMIC	MKENS	DEG_APCC_KENBOX_2	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons