DegronMD

Uniprot ID: Q5T5P2

Source protein: Sickle tail protein homolog

Source gene: KIAA1217

Class: DEG_SCF_FBW7_2

Location: 1422:1427

E3 ligase: FBXW7

DEGRON score: 0.7898

ASA_SCORE: 121.1667

COIL: 0.9397

CONS_SCORE: 0.283

DSS_SCORE: 0.6401

HELIX: 0.0335

FCONS_SCORE: 0.835

RIG_SCORE: 0.6909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1417N	TCGA-AX-A05Z	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	TCGA-BS-A0UV	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	TCGA-E6-A1LX	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	TCGA-VQ-AA6A	STAD	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	DO222387	STAD	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	DO40884	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	DO41020	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.D1417N	DO42793	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.1944
p.V1414G	TCGA-DI-A2QY	UCEC	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.1111
p.V1414G	DO42031	UCEC	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.1111
p.P1424S	TCGA-GF-A6C9	SKCM	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.6752
p.P1424S	DO51254	SKCM	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.6752
p.V1436M	TCGA-OR-A5K4	ACC	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.0833
p.V1436M	DO227587	COCA	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.0833
p.D1430N	TCGA-XF-AAN5	BLCA	TCGA	MTPRQE	DEG_SCF_FBW7_2	0.25
p.D1430N	DO51945	BLCA	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.25
p.D1430G	DO222427	BTCA	ICGC	MTPRQE	DEG_SCF_FBW7_2	0.25
p.T1423A	SIDM01727	Chronic Myelogenous Leukemia	GDSC	MTPRQE	DEG_SCF_FBW7_2	0.7139
p.Q1426K	ACH-000117	Breast Cancer	CCLE	MTPRQE	DEG_SCF_FBW7_2	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5P2	Sickle tail protein homolog	DEG_SCF_FBW7_2	1422:1427	MTPRQE	FBXW7	0.7898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons