DegronMD

Uniprot ID: Q5T5P2

Source protein: Sickle tail protein homolog

Source gene: KIAA1217

Class: DEG_APCC_KENBOX_2

Location: 1075:1079

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9909

ASA_SCORE: 126.24

COIL: 0.9146

CONS_SCORE: 0.3175

DSS_SCORE: 0.5803

HELIX: 0.0398

FCONS_SCORE: 0.8847

RIG_SCORE: 0.7453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1069N	TCGA-B5-A3FC	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.1667
p.K1082N	TCGA-BR-A4CQ	STAD	TCGA	RKENI	DEG_APCC_KENBOX_2	0.3611
p.K1082E	TCGA-PG-A5BC	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	0.3611
p.G1074S	SIDM00819	Kidney Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.3056
p.G1089R	SIDM00011	Melanoma	GDSC	RKENI	DEG_APCC_KENBOX_2	0.0556
p.E1066K	SW900	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.0833
p.T1074N	LN-229	central_nervous_system	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.3056
p.P1077L	FADU	upper_aerodigestive_tract	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.7582
p.K1076N	CW-2	large_intestine	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.6918
p.P1078L	FADU	upper_aerodigestive_tract	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.7582
p.E1067K	SW900	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.5556
p.T1073N	LN-229	central_nervous_system	COSMIC	RKENI	DEG_APCC_KENBOX_2	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_APCC_KENBOX_2	86:90	RKENI	APC,CDC20,FZR1	0.9334	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_APCC_KENBOX_2	461:465	RKENI	APC,CDC20,FZR1	0.9638	More...
Q5T5P2	Sickle tail protein homolog	DEG_APCC_KENBOX_2	1075:1079	RKENI	APC,CDC20,FZR1	0.9909	More...
Q8N7X0	Androglobin	DEG_APCC_KENBOX_2	1508:1512	RKENI	APC,CDC20,FZR1	0.8902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons