DegronMD - O43166(SIPA1L1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S162A	TCGA-17-Z022	LUAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.75
p.P1726L	TCGA-18-3409	LUSC	TCGA	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7582
p.P1726L	DO26444	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7582
p.P1350H	TCGA-2W-A8YY	CESC	TCGA	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.3056
p.P1350H	DO223732	CESC	ICGC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.3056
p.V1359A	TCGA-2W-A8YY	CESC	TCGA	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.0556
p.V1359A	DO223732	CESC	ICGC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.0556
p.S1342L	TCGA-49-4507	LUAD	TCGA	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.25
p.S1342L	DO25727	LUAD	ICGC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.25
p.T1019M	TCGA-A5-A0G1	UCEC	TCGA	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1667
p.T1019M	TCGA-AA-A01R	COAD	TCGA	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1667
p.T1019M	DO7934	COAD	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1667
p.T1019M	DO42472	UCEC	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1667
p.S174N	TCGA-A6-6781	COAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.6944
p.S174N	DO8447	COAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.6944
p.V76I	TCGA-AX-A2HC	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0556
p.V76I	DO41572	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0556
p.R171H	TCGA-B5-A3FA	UCEC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7133
p.R171H	TCGA-DI-A1BU	UCEC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7133
p.R171H	DO42023	UCEC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7133
p.R171H	DO52402	UCEC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7133
p.P1033S	TCGA-BG-A0M7	UCEC	TCGA	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.25
p.P1033S	DO42089	UCEC	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.25
p.M155I	TCGA-BR-6452	STAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1111
p.M155I	DO38404	STAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1111
p.R168C	TCGA-BR-6801	STAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R168C	TCGA-D1-A103	UCEC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R168C	TCGA-D3-A3C8	SKCM	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R168C	DO47636	SKCM	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R168C	DO38253	STAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R168C	DO42312	UCEC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R1351C	TCGA-BS-A0UV	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.2778
p.R1351C	TCGA-EY-A1GI	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.2778
p.R1351C	DO41211	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.2778
p.R1351C	DO42793	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.2778
p.S1739Y	TCGA-BS-A0UV	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation blocking phosphorylation signal	0.5278
p.S1739Y	DO42793	UCEC	ICGC	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation blocking phosphorylation signal	0.5278
p.A158T	TCGA-CD-A4MG	STAD	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1944
p.A158T	DO48009	STAD	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1944
p.E92K	TCGA-D1-A16X	UCEC	TCGA	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2778
p.E92K	DO41799	UCEC	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2778
p.P1027Q	TCGA-D3-A2JD	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.7035
p.P1027Q	TCGA-EE-A2GT	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.7035
p.P1027Q	DO37543	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.7035
p.P1027Q	DO37946	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.7035
p.R86K	TCGA-EE-A2MN	SKCM	TCGA	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.6126
p.R86K	DO222438	MELA	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.6126
p.R86K	DO37423	SKCM	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.6126
p.Y1727C	TCGA-EM-A22Q	THCA	TCGA	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7087
p.Y1727C	DO40141	THCA	ICGC	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation altering degron motif	0.7087
p.P1335H	TCGA-ER-A19N	SKCM	TCGA	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.2222
p.P1335H	TCGA-ER-A19N	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.0556
p.P1335H	DO37452	SKCM	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.2222
p.P1335H	DO37452	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.0556
p.P160H	TCGA-ER-A2NH	SKCM	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.P160H	DO47683	SKCM	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.25
p.D1732Y	TCGA-IB-7651	PAAD	TCGA	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.2778
p.D1732Y	DO46657	PAAD	ICGC	PYSSS	DEG_SPOP_SBC_1	1726:1730	Mutation rewiring degron network	0.2778
p.V76A	TCGA-MA-AA42	CESC	TCGA	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0556
p.V76A	DO219724	CESC	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0556
p.R173Q	TCGA-VS-A959	CESC	TCGA	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.2778
p.R173Q	DO51640	CESC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.2778
p.S162C	DO2287	BRCA	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.75
p.R171C	DO227987	COCA	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.719
p.R168H	DO222884	COCA	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7133
p.R95H	DO233168	GACA	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1944
p.R95H	ACH-001515	Cervical Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1944
p.A1324S	DO229018	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.3056
p.G1334V	DO229026	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.25
p.G1321V	DO229009	LICA	ICGC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.2222
p.S162F	DO229177	LMS	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.75
p.S174C	DO224563	LUSC	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.6944
p.P1026I	DO220886	MELA	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.6145
p.P1026T	DO220886	MELA	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.5919
p.P1026L	DO220886	MELA	ICGC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.6471
p.P85S	DO222843	MELA	ICGC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.3056
p.P169L	DO50288	SKCM	ICGC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation altering degron motif	0.7582
p.S176I	SIDM00683	Prostate Carcinoma	GDSC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.6389
p.S176I	ACH-000977	lymph node	CCLE	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.6389
p.S176I	LNCaP-Clone-FGC	prostate	COSMIC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation blocking phosphorylation signal	0.6389
p.N1317D	SIDM01197	Colorectal Carcinoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1111
p.N1317D	SNU-C1	large intestine	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1111
p.V1359M	SIDM01483	Melanoma	GDSC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.0556
p.V1359M	COLO-741	large intestine	COSMIC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.0556
p.G1338S	SIDM00258	Neuroblastoma	GDSC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1389
p.G1338S	SIDM00258	Neuroblastoma	GDSC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.1389
p.G1338S	NB12	autonomic ganglia	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1389
p.G1338S	NB12	autonomic ganglia	COSMIC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.1389
p.E157K	SIDM00905	Cervical Carcinoma	GDSC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1667
p.E157K	ACH-001334	Cervical Cancer	CCLE	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1667
p.E157K	ACH-001335	Cervical Cancer	CCLE	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1667
p.E157K	C-4-I	cervix	COSMIC	PRKALRRIR	DEG_APCC_DBOX_1	163:171	Mutation rewiring degron network	0.1667
p.S1038C	SIDM01217	Other Blood Cancers	GDSC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1111
p.S1038C	ACH-002276	Leukemia	CCLE	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1111
p.S1038C	MY-M12	haematopoietic and lymphoid tissue	COSMIC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.1111
p.V1022I	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.25
p.V1022I	ACH-000900	Lung Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.25
p.V1022I	NCI-H23	lung	COSMIC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation rewiring degron network	0.25
p.S94I	SIDM00279	Gastric Carcinoma	GDSC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2222
p.S94I	ACH-000225	Gastric Cancer	CCLE	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2222
p.S94I	ECC12	stomach	COSMIC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2222
p.V1338M	ACH-000582	Skin Cancer	CCLE	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1389
p.V1338M	ACH-000582	Skin Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.1389
p.V1338M	COLO-741	large intestine	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1389
p.V1338M	COLO-741	large intestine	COSMIC	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation rewiring degron network	0.1389
p.L1356S	ACH-001719	Ovarian Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	1345:1349	Mutation substituting flanking lysine	0.25
p.D1029N	ACH-001863	Bile Duct Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.5821
p.G1317S	ACH-002279	Neuroblastoma	CCLE	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1111
p.G1317S	NB12	autonomic ganglia	COSMIC	DSGIDTT	DEG_SCF_TRCP1_1	1325:1331	Mutation rewiring degron network	0.1111
p.N83K	NCI-H740	lung	COSMIC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S1026I	NCI-H650	lung	COSMIC	IPPHDD	LIG_APCC_ABBA_1	1025:1030	Mutation altering degron motif	0.7341
p.E100K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	RKENI	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIPA1L1

UniProt ID: O43166

Entrez ID: 26037

Protein name: Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIPA1L1 in