DegronMD

Uniprot ID: O43166

Source protein: Signal-induced proliferation-associated 1-like protein 1

Source gene: SIPA1L1

Class: LIG_APCC_ABBA_1

Location: 1025:1030

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9365

ASA_SCORE: 65.8

COIL: 0.7805

CONS_SCORE: 0.4796

DSS_SCORE: 0.2813

HELIX: 0.0158

FCONS_SCORE: 1.0246

RIG_SCORE: 0.7852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1019M	TCGA-A5-A0G1	UCEC	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.T1019M	TCGA-AA-A01R	COAD	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.T1019M	DO7934	COAD	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.T1019M	DO42472	UCEC	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.P1033S	TCGA-BG-A0M7	UCEC	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.25
p.P1033S	DO42089	UCEC	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.25
p.P1027Q	TCGA-D3-A2JD	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.7035
p.P1027Q	TCGA-EE-A2GT	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.7035
p.P1027Q	DO37543	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.7035
p.P1027Q	DO37946	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.7035
p.P1026I	DO220886	MELA	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.6145
p.P1026T	DO220886	MELA	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.5919
p.P1026L	DO220886	MELA	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.6471
p.S1038C	SIDM01217	Other Blood Cancers	GDSC	IPPHDD	LIG_APCC_ABBA_1	0.1111
p.S1038C	ACH-002276	Leukemia	CCLE	IPPHDD	LIG_APCC_ABBA_1	0.1111
p.S1038C	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	IPPHDD	LIG_APCC_ABBA_1	0.1111
p.V1022I	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	IPPHDD	LIG_APCC_ABBA_1	0.25
p.V1022I	ACH-000900	Lung Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	0.25
p.V1022I	NCI-H23	lung	COSMIC	IPPHDD	LIG_APCC_ABBA_1	0.25
p.D1029N	ACH-001863	Bile Duct Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	0.5821
p.S1026I	NCI-H650	lung	COSMIC	IPPHDD	LIG_APCC_ABBA_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	LIG_APCC_ABBA_1	1025:1030	IPPHDD	APC,CDC20,FZR1	0.9365	More...
Q6R327	Rapamycin-insensitive companion of mTOR	LIG_APCC_ABBA_1	1450:1455	IPPHDD	APC,CDC20,FZR1	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons