DegronMD

Uniprot ID: Q6R327

Source protein: Rapamycin-insensitive companion of mTOR

Source gene: RICTOR

Class: LIG_APCC_ABBA_1

Location: 1450:1455

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9917

ASA_SCORE: 81.2167

COIL: 0.82

CONS_SCORE: 0.2485

DSS_SCORE: 0.4799

HELIX: 0.1383

FCONS_SCORE: 1.1109

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1452S	TCGA-5L-AAT0	BRCA	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.6752
p.P1452S	DO219593	BRCA	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.6752
p.P1452L	TCGA-DX-A6BA	SARC	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.6471
p.P1452L	DO219995	SARC	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.6471
p.F1461Y	TCGA-EE-A29S	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.F1461Y	DO37936	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.F1461L	TCGA-EE-A29S	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.F1461L	DO37936	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.1667
p.D1455N	TCGA-G4-6628	COAD	TCGA	IPPHDD	LIG_APCC_ABBA_1	0.6932
p.D1455N	DO10132	COAD	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.6932
p.A1465E	DO229036	LICA	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.0556
p.N1449K	DO229036	LICA	ICGC	IPPHDD	LIG_APCC_ABBA_1	0.3056
p.I1442S	ACH-000048	Ovarian Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	0.1111
p.I1442S	TOV-112D	ovary	COSMIC	IPPHDD	LIG_APCC_ABBA_1	0.1111
p.Q1446K	ACH-001552	Skin Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	0.2222
p.Q1446K	MCC26	skin	COSMIC	IPPHDD	LIG_APCC_ABBA_1	0.2222
p.A1462V	ACH-002045	Head and Neck Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	0.1389
p.A1462V	HO-1-u-1	upper_aerodigestive_tract	COSMIC	IPPHDD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43166	Signal-induced proliferation-associated 1-like protein 1	LIG_APCC_ABBA_1	1025:1030	IPPHDD	APC,CDC20,FZR1	0.9365	More...
Q6R327	Rapamycin-insensitive companion of mTOR	LIG_APCC_ABBA_1	1450:1455	IPPHDD	APC,CDC20,FZR1	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons