DegronMD - Q6R327(RICTOR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1346C	TCGA-50-6593	LUAD	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation blocking phosphorylation signal	0.5
p.S1346C	DO24100	LUAD	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation blocking phosphorylation signal	0.5
p.P266Q	TCGA-50-6673	LUAD	TCGA	LAPYTD	LIG_APCC_ABBA_1	254:259	Mutation rewiring degron network	0.1389
p.P266Q	DO24218	LUAD	ICGC	LAPYTD	LIG_APCC_ABBA_1	254:259	Mutation rewiring degron network	0.1389
p.R1200Q	TCGA-56-7223	LUSC	TCGA	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1944
p.R1200Q	DO26999	LUSC	ICGC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1944
p.P1452S	TCGA-5L-AAT0	BRCA	TCGA	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation altering degron motif	0.6752
p.P1452S	DO219593	BRCA	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation altering degron motif	0.6752
p.P1354S	TCGA-5N-A9KI	BLCA	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.2778
p.P1354S	DO223513	BLCA	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.2778
p.S1353Y	TCGA-A5-A0G2	UCEC	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation blocking phosphorylation signal	0.6944
p.S1353Y	DO41235	UCEC	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation blocking phosphorylation signal	0.6944
p.A1350S	TCGA-AG-A002	READ	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.1667
p.T258S	TCGA-DD-AAD8	LIHC	TCGA	LAPYTD	LIG_APCC_ABBA_1	254:259	Mutation altering degron motif	0.6005
p.T258S	DO52226	LIHC	ICGC	LAPYTD	LIG_APCC_ABBA_1	254:259	Mutation altering degron motif	0.6005
p.P1452L	TCGA-DX-A6BA	SARC	TCGA	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation altering degron motif	0.6471
p.P1452L	DO219995	SARC	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation altering degron motif	0.6471
p.F1461Y	TCGA-EE-A29S	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1667
p.F1461Y	DO37936	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1667
p.F1461L	TCGA-EE-A29S	SKCM	TCGA	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1667
p.F1461L	DO37936	SKCM	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1667
p.D1455N	TCGA-G4-6628	COAD	TCGA	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation altering degron motif	0.6932
p.D1455N	DO10132	COAD	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation altering degron motif	0.6932
p.R1216H	TCGA-VQ-A91D	STAD	TCGA	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1389
p.R1216H	DO51783	STAD	ICGC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1389
p.R1216H	SIDM01608	Endometrial Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1389
p.R1216H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1389
p.T1363I	TCGA-W3-A825	SKCM	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.3056
p.T1363I	DO51272	SKCM	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.3056
p.E1196Q	TCGA-ZF-A9R0	BLCA	TCGA	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.0833
p.E1196Q	DO219055	BLCA	ICGC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.0833
p.V1204I	DO224855	BRCA	ICGC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.3056
p.R1216C	DO233088	GACA	ICGC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation rewiring degron network	0.1389
p.T1209M	DO233089	GACA	ICGC	VESST	DEG_SPOP_SBC_1	1205:1209	Mutation altering degron motif	0.7423
p.S1348C	DO233949	GACA	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation blocking phosphorylation signal	0.5556
p.A246S	DO228278	LICA	ICGC	LAPYTD	LIG_APCC_ABBA_1	254:259	Mutation rewiring degron network	0.1111
p.A1465E	DO229036	LICA	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.0556
p.N1449K	DO229036	LICA	ICGC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.3056
p.E1349K	SIDM00630	Breast Carcinoma	GDSC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.1389
p.E1349K	ACH-000876	Breast Cancer	CCLE	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.1389
p.T1365I	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.25
p.T1365I	ACH-002392	Lymphoma	CCLE	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.25
p.T1365I	SC-1	haematopoietic and lymphoid tissue	COSMIC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	1356:1362	Mutation rewiring degron network	0.25
p.I1442S	ACH-000048	Ovarian Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1111
p.I1442S	TOV-112D	ovary	COSMIC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1111
p.Q1446K	ACH-001552	Skin Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.2222
p.Q1446K	MCC26	skin	COSMIC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.2222
p.A1462V	ACH-002045	Head and Neck Cancer	CCLE	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1389
p.A1462V	HO-1-u-1	upper aerodigestive tract	COSMIC	IPPHDD	LIG_APCC_ABBA_1	1450:1455	Mutation rewiring degron network	0.1389

Kaplan plot for RICTOR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RICTOR

UniProt ID: Q6R327

Entrez ID: 253260

Protein name: Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RICTOR in