DegronMD

Uniprot ID: Q6R327

Source protein: Rapamycin-insensitive companion of mTOR

Source gene: RICTOR

Class: LIG_APCC_ABBA_1

Location: 254:259

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9559

ASA_SCORE: 8.7333

COIL: 0.3232

CONS_SCORE: 0.5083

DSS_SCORE: 0.2856

HELIX: 0.4748

FCONS_SCORE: 1.4578

RIG_SCORE: 0.7877

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P266Q	TCGA-50-6673	LUAD	TCGA	LAPYTD	LIG_APCC_ABBA_1	0.1389
p.P266Q	DO24218	LUAD	ICGC	LAPYTD	LIG_APCC_ABBA_1	0.1389
p.T258S	TCGA-DD-AAD8	LIHC	TCGA	LAPYTD	LIG_APCC_ABBA_1	0.6005
p.T258S	DO52226	LIHC	ICGC	LAPYTD	LIG_APCC_ABBA_1	0.6005
p.A246S	DO228278	LICA	ICGC	LAPYTD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6R327	Rapamycin-insensitive companion of mTOR	LIG_APCC_ABBA_1	254:259	LAPYTD	APC,CDC20,FZR1	0.9559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons