DegronMD

Uniprot ID: Q6R327

Source protein: Rapamycin-insensitive companion of mTOR

Source gene: RICTOR

Class: LIG_APCC_ABBAyCdc20_2

Location: 1356:1362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9753

ASA_SCORE: 68.1429

COIL: 0.6621

CONS_SCORE: 0.2525

DSS_SCORE: 0.2784

HELIX: 0.2764

FCONS_SCORE: 1.0396

RIG_SCORE: 0.8006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1346C	TCGA-50-6593	LUAD	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.5
p.S1346C	DO24100	LUAD	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.5
p.P1354S	TCGA-5N-A9KI	BLCA	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1354S	DO223513	BLCA	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1353Y	TCGA-A5-A0G2	UCEC	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.6944
p.S1353Y	DO41235	UCEC	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.6944
p.A1350S	TCGA-AG-A002	READ	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T1363I	TCGA-W3-A825	SKCM	TCGA	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T1363I	DO51272	SKCM	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S1348C	DO233949	GACA	ICGC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.5556
p.E1349K	SIDM00630	Breast Carcinoma	GDSC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E1349K	ACH-000876	Breast Cancer	CCLE	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T1365I	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.T1365I	ACH-002392	Lymphoma	CCLE	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.T1365I	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	KDVLFTD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6R327	Rapamycin-insensitive companion of mTOR	LIG_APCC_ABBAyCdc20_2	1356:1362	KDVLFTD	APC,CDC20,FZR1	0.9753	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons