DegronMD

Uniprot ID: Q6R327

Source protein: Rapamycin-insensitive companion of mTOR

Source gene: RICTOR

Class: DEG_SPOP_SBC_1

Location: 1205:1209

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 92.06

COIL: 0.7628

CONS_SCORE: 0.2403

DSS_SCORE: 0.5953

HELIX: 0.2198

FCONS_SCORE: 1.0548

RIG_SCORE: 0.7016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1200Q	TCGA-56-7223	LUSC	TCGA	VESST	DEG_SPOP_SBC_1	0.1944
p.R1200Q	DO26999	LUSC	ICGC	VESST	DEG_SPOP_SBC_1	0.1944
p.R1216H	TCGA-VQ-A91D	STAD	TCGA	VESST	DEG_SPOP_SBC_1	0.1389
p.R1216H	DO51783	STAD	ICGC	VESST	DEG_SPOP_SBC_1	0.1389
p.R1216H	SIDM01608	Endometrial Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	0.1389
p.R1216H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VESST	DEG_SPOP_SBC_1	0.1389
p.E1196Q	TCGA-ZF-A9R0	BLCA	TCGA	VESST	DEG_SPOP_SBC_1	0.0833
p.E1196Q	DO219055	BLCA	ICGC	VESST	DEG_SPOP_SBC_1	0.0833
p.V1204I	DO224855	BRCA	ICGC	VESST	DEG_SPOP_SBC_1	0.3056
p.R1216C	DO233088	GACA	ICGC	VESST	DEG_SPOP_SBC_1	0.1389
p.T1209M	DO233089	GACA	ICGC	VESST	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	318:322	VESST	SPOP	0.9996	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	675:679	VESST	SPOP	0.842	More...
Q6R327	Rapamycin-insensitive companion of mTOR	DEG_SPOP_SBC_1	1205:1209	VESST	SPOP	0.9971	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	DEG_SPOP_SBC_1	2013:2017	VESST	SPOP	0.7453	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	581:585	VESST	SPOP	0.9759	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	23:27	VESST	SPOP	0.9811	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	346:350	VESST	SPOP	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons