DegronMD - O76039(CDKL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S321I	TCGA-04-1649	OV	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7341
p.S321I	DO32467	OV	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7341
p.G330C	TCGA-09-2044	OV	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.G330C	DO28923	OV	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1111
p.K314Q	TCGA-85-6561	LUSC	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation blocking ubiquitination signal	0.6667
p.K314Q	DO26518	LUSC	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation blocking ubiquitination signal	0.6667
p.R313I	TCGA-AX-A05Z	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1944
p.R313I	DO40884	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1944
p.P390H	TCGA-AX-A06F	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7694
p.P390H	DO41752	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7694
p.A311S	TCGA-CV-5978	HNSC	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.A311S	DO16023	HNSC	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.T383A	TCGA-EO-A3AY	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1389
p.T383A	DO43202	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1389
p.T322A	TCGA-EY-A215	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7139
p.T322A	DO42665	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7139
p.V318M	TCGA-F5-6571	READ	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7208
p.V318M	DO36874	READ	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7208
p.P315L	TCGA-FI-A2D0	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.P315L	DO43891	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.25
p.A311T	SIDM00602	Gastric Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.A311T	ACH-000919	Gastric Cancer	CCLE	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.A311T	IM-95	stomach	COSMIC	VESST	DEG_SPOP_SBC_1	318:322	Mutation rewiring degron network	0.1389
p.S321N	SIDM00329	Hodgkin's Lymphoma	GDSC	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7069
p.S321N	ACH-000806	Lymphoma	CCLE	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7069
p.S321N	L-540	haematopoietic and lymphoid tissue	COSMIC	VESST	DEG_SPOP_SBC_1	318:322	Mutation altering degron motif	0.7069
p.Y384C	SIDM01612	Endometrial Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1667
p.Y384C	ACH-000946	Endometrial/Uterine Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1667
p.H404P	ACH-001539	Lymphoma	CCLE	PGSTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0556

Kaplan plot for CDKL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDKL5

UniProt ID: O76039

Entrez ID: 6792

Protein name: Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine-protein kinase 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDKL5 in