DegronMD

Uniprot ID: O76039

Source protein: Cyclin-dependent kinase-like 5

Source gene: CDKL5

Class: DEG_SPOP_SBC_1

Location: 318:322

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 100.48

COIL: 0.8278

CONS_SCORE: 0.4024

DSS_SCORE: 0.684

HELIX: 0.1516

FCONS_SCORE: 1.1365

RIG_SCORE: 0.6609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S321I	TCGA-04-1649	OV	TCGA	VESST	DEG_SPOP_SBC_1	0.7341
p.S321I	DO32467	OV	ICGC	VESST	DEG_SPOP_SBC_1	0.7341
p.G330C	TCGA-09-2044	OV	TCGA	VESST	DEG_SPOP_SBC_1	0.1111
p.G330C	DO28923	OV	ICGC	VESST	DEG_SPOP_SBC_1	0.1111
p.K314Q	TCGA-85-6561	LUSC	TCGA	VESST	DEG_SPOP_SBC_1	0.6667
p.K314Q	DO26518	LUSC	ICGC	VESST	DEG_SPOP_SBC_1	0.6667
p.R313I	TCGA-AX-A05Z	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	0.1944
p.R313I	DO40884	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	0.1944
p.A311S	TCGA-CV-5978	HNSC	TCGA	VESST	DEG_SPOP_SBC_1	0.1389
p.A311S	DO16023	HNSC	ICGC	VESST	DEG_SPOP_SBC_1	0.1389
p.T322A	TCGA-EY-A215	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	0.7139
p.T322A	DO42665	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	0.7139
p.V318M	TCGA-F5-6571	READ	TCGA	VESST	DEG_SPOP_SBC_1	0.7208
p.V318M	DO36874	READ	ICGC	VESST	DEG_SPOP_SBC_1	0.7208
p.P315L	TCGA-FI-A2D0	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	0.25
p.P315L	DO43891	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	0.25
p.A311T	SIDM00602	Gastric Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	0.1389
p.A311T	ACH-000919	Gastric Cancer	CCLE	VESST	DEG_SPOP_SBC_1	0.1389
p.A311T	IM-95	stomach	COSMIC	VESST	DEG_SPOP_SBC_1	0.1389
p.S321N	SIDM00329	Hodgkin's Lymphoma	GDSC	VESST	DEG_SPOP_SBC_1	0.7069
p.S321N	ACH-000806	Lymphoma	CCLE	VESST	DEG_SPOP_SBC_1	0.7069
p.S321N	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	VESST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	318:322	VESST	SPOP	0.9996	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	675:679	VESST	SPOP	0.842	More...
Q6R327	Rapamycin-insensitive companion of mTOR	DEG_SPOP_SBC_1	1205:1209	VESST	SPOP	0.9971	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	DEG_SPOP_SBC_1	2013:2017	VESST	SPOP	0.7453	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	581:585	VESST	SPOP	0.9759	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	23:27	VESST	SPOP	0.9811	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	346:350	VESST	SPOP	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons