DegronMD - Q9H8J5(MANSC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M343I	TCGA-28-1760	GBM	TCGA	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.25
p.T229M	TCGA-85-7844	LUSC	TCGA	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.1667
p.T229M	TCGA-BR-8487	STAD	TCGA	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.1667
p.L247P	TCGA-85-7950	LUSC	TCGA	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1389
p.L247P	TCGA-85-7950	LUSC	TCGA	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.1111
p.S348Y	TCGA-AJ-A3EL	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.712
p.T354A	TCGA-AZ-6598	COAD	TCGA	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.G359D	TCGA-B8-5550	KIRC	TCGA	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0833
p.T339A	TCGA-BR-4361	STAD	TCGA	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1389
p.Y341S	DO44115	BRCA	ICGC	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.T251A	DO3095	BRCA	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.25
p.S261Y	DO222884	COCA	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.2778
p.V265M	DO233854	GACA	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1667
p.M262I	DO13725	GBM	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.25
p.A259E	DO229041	LICA	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.7701
p.E243D	DO232858	NACA	ICGC	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation substituting flanking lysine	0.3333
p.D340G	DO50291	SKCM	ICGC	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1667
p.T258A	DO38887	STAD	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.7139
p.S267Y	DO41542	UCEC	ICGC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.1111
p.S239L	SIDM01117	Small Cell Lung Carcinoma	GDSC	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation altering degron motif	0.7667
p.S239L	SIDM00656	Burkitt's Lymphoma	GDSC	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation altering degron motif	0.7667
p.S239L	SIDM00641	Burkitt's Lymphoma	GDSC	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation altering degron motif	0.7667
p.T350S	SIDM01162	Kidney Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6005
p.T350S	SIDM01076	B-Lymphoblastic Leukemia	GDSC	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6005
p.T350S	ACH-000070	Leukemia	CCLE	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6005
p.T350S	ACH-001398	Kidney Cancer	CCLE	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6005
p.T350S	697	haematopoietic and lymphoid tissue	COSMIC	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6005
p.T350S	SW156	kidney	COSMIC	VESST	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.6005
p.A355V	SIDM01059	Melanoma	GDSC	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.T269S	697	haematopoietic and lymphoid tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.0556
p.T269S	SW156	kidney	COSMIC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.0556
p.D231Y	NCCIT	testis	COSMIC	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.2222
p.A258V	RC-K8	haematopoietic and lymphoid tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation altering degron motif	0.6936
p.G252E	HH	haematopoietic and lymphoid tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.2778
p.Y341D	HT-115	large intestine	COSMIC	VESST	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.T242I	KNS-81-FD	central nervous system	COSMIC	PHTTS	DEG_SPOP_SBC_1	235:239	Mutation rewiring degron network	0.25
p.M263R	NOS-1	bone	COSMIC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.2222
p.F253I	SW684	soft tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	254:259	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MANSC1

UniProt ID: Q9H8J5

Entrez ID: 54682

Protein name: MANSC domain-containing protein 1 (Loss of heterozygosity 12 chromosomal region 3 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MANSC1 in