DegronMD

Uniprot ID: Q9H8J5

Source protein: MANSC domain-containing protein 1

Source gene: MANSC1

Class: DEG_SCF_FBW7_1

Location: 254:259

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 82.4

COIL: 0.9557

CONS_SCORE: 0.5382

DSS_SCORE: 0.6046

HELIX: 0.012

FCONS_SCORE: 1.1885

RIG_SCORE: 0.6039

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L247P	TCGA-85-7950	LUSC	TCGA	VTPSGT	DEG_SCF_FBW7_1	0.1389
p.T251A	DO3095	BRCA	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.25
p.S261Y	DO222884	COCA	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.2778
p.V265M	DO233854	GACA	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.1667
p.M262I	DO13725	GBM	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.25
p.A259E	DO229041	LICA	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.7701
p.T258A	DO38887	STAD	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.7139
p.S267Y	DO41542	UCEC	ICGC	VTPSGT	DEG_SCF_FBW7_1	0.1111
p.T269S	697	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	0.0556
p.T269S	SW156	kidney	COSMIC	VTPSGT	DEG_SCF_FBW7_1	0.0556
p.A258V	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	0.6936
p.G252E	HH	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	0.2778
p.M263R	NOS-1	bone	COSMIC	VTPSGT	DEG_SCF_FBW7_1	0.2222
p.F253I	SW684	soft_tissue	COSMIC	VTPSGT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8J5	MANSC domain-containing protein 1	DEG_SCF_FBW7_1	254:259	VTPSGT	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons