DegronMD

Uniprot ID: Q9H8J5

Source protein: MANSC domain-containing protein 1

Source gene: MANSC1

Class: DEG_SPOP_SBC_1

Location: 235:239

E3 ligase: SPOP

DEGRON score: 0.9619

ASA_SCORE: 102.74

COIL: 0.955

CONS_SCORE: 0.4844

DSS_SCORE: 0.528

HELIX: 0.0146

FCONS_SCORE: 1.0289

RIG_SCORE: 0.6457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T229M	TCGA-85-7844	LUSC	TCGA	PHTTS	DEG_SPOP_SBC_1	0.1667
p.T229M	TCGA-BR-8487	STAD	TCGA	PHTTS	DEG_SPOP_SBC_1	0.1667
p.L247P	TCGA-85-7950	LUSC	TCGA	PHTTS	DEG_SPOP_SBC_1	0.1111
p.E243D	DO232858	NACA	ICGC	PHTTS	DEG_SPOP_SBC_1	0.3333
p.S239L	SIDM01117	Small Cell Lung Carcinoma	GDSC	PHTTS	DEG_SPOP_SBC_1	0.7667
p.S239L	SIDM00656	Burkitt's Lymphoma	GDSC	PHTTS	DEG_SPOP_SBC_1	0.7667
p.S239L	SIDM00641	Burkitt's Lymphoma	GDSC	PHTTS	DEG_SPOP_SBC_1	0.7667
p.D231Y	NCCIT	testis	COSMIC	PHTTS	DEG_SPOP_SBC_1	0.2222
p.T242I	KNS-81-FD	central_nervous_system	COSMIC	PHTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	846:850	PHTTS	SPOP	0.9409	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1589:1593	PHTTS	SPOP	0.8702	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	235:239	PHTTS	SPOP	0.9619	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons