DegronMD

Uniprot ID: Q53TQ3

Source protein: INO80 complex subunit D

Source gene: INO80D

Class: DEG_SPOP_SBC_1

Location: 846:850

E3 ligase: SPOP

DEGRON score: 0.9409

ASA_SCORE: 77.84

COIL: 0.8402

CONS_SCORE: 0.3343

DSS_SCORE: 0.5482

HELIX: 0.0466

FCONS_SCORE: 0.9187

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A857S	TCGA-75-6214	LUAD	TCGA	PHTTS	DEG_SPOP_SBC_1	0.1389
p.A857S	DO24830	LUAD	ICGC	PHTTS	DEG_SPOP_SBC_1	0.1389
p.S850L	TCGA-A5-A0G2	UCEC	TCGA	PHTTS	DEG_SPOP_SBC_1	0.7667
p.S850L	DO41235	UCEC	ICGC	PHTTS	DEG_SPOP_SBC_1	0.7667
p.P846L	TCGA-FW-A3R5	SKCM	TCGA	PHTTS	DEG_SPOP_SBC_1	0.7582
p.P846L	DO37406	SKCM	ICGC	PHTTS	DEG_SPOP_SBC_1	0.7582
p.M856V	TCGA-HU-A4H0	STAD	TCGA	PHTTS	DEG_SPOP_SBC_1	0.1667
p.M856V	DO47785	STAD	ICGC	PHTTS	DEG_SPOP_SBC_1	0.1667
p.H842R	DO230961	LUSC	ICGC	PHTTS	DEG_SPOP_SBC_1	0.2222
p.H842R	DO224594	LUSC	ICGC	PHTTS	DEG_SPOP_SBC_1	0.2222
p.Y851C	ACH-000961	Endometrial/Uterine Cancer	CCLE	PHTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	846:850	PHTTS	SPOP	0.9409	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1589:1593	PHTTS	SPOP	0.8702	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	235:239	PHTTS	SPOP	0.9619	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons