DegronMD - Q7Z5N4(SDK1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1600H	TCGA-09-2044	OV	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.1111
p.Q1600H	TCGA-09-2044	OV	TCGA	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.1389
p.Q1600H	DO229045	LICA	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.1111
p.Q1600H	DO229045	LICA	ICGC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.1389
p.Q1600H	DO28923	OV	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.1111
p.Q1600H	DO28923	OV	ICGC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.1389
p.E1124D	TCGA-43-3920	LUSC	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5647
p.E1124D	TCGA-AP-A059	UCEC	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5647
p.E1124D	DO26445	LUSC	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5647
p.E1124D	DO41361	UCEC	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5647
p.G1113S	TCGA-49-6743	LUAD	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1667
p.G1113S	DO26092	LUAD	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1667
p.R606L	TCGA-49-AAR2	LUAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.7316
p.R606L	DO218918	LUAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.7316
p.G630E	TCGA-49-AAR2	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1111
p.G630E	DO218918	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1111
p.D600E	TCGA-55-8511	LUAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.3056
p.D600E	DO24940	LUAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.3056
p.V608I	TCGA-AX-A2HC	UCEC	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5965
p.V608I	DO41572	UCEC	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5965
p.V608I	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5965
p.V608I	ACH-000073	Lymphoma	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5965
p.V608I	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.5965
p.A1587T	TCGA-B5-A5OC	UCEC	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.6028
p.A1587T	DO52405	UCEC	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.6028
p.R606C	TCGA-B6-A0IC	BRCA	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.R606C	DO4928	BRCA	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.719
p.P1602Q	TCGA-BR-4362	STAD	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.0556
p.P1602Q	TCGA-BR-4362	STAD	TCGA	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.P1602Q	DO38336	STAD	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.0556
p.P1602Q	DO38336	STAD	ICGC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.T598A	TCGA-CG-4306	STAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.25
p.T598A	DO38567	STAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.25
p.S1594F	TCGA-D3-A2JP	SKCM	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.2778
p.S1594F	TCGA-D3-A2JP	SKCM	TCGA	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.3056
p.S1594F	DO47407	SKCM	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.2778
p.S1594F	DO47407	SKCM	ICGC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.3056
p.E1134D	TCGA-D9-A148	SKCM	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.0556
p.E1134D	DO37971	SKCM	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.0556
p.P1602L	TCGA-DC-6158	READ	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.0556
p.P1602L	TCGA-DC-6158	READ	TCGA	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.P1602L	DO37197	READ	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.0556
p.P1602L	DO37197	READ	ICGC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.P1602L	SIDM01060	Melanoma	GDSC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.0556
p.P1602L	SIDM01060	Melanoma	GDSC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.P1602L	IGR-1	skin	COSMIC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.0556
p.P1602L	IGR-1	skin	COSMIC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.G630R	TCGA-DC-6682	READ	TCGA	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1111
p.G630R	DO37162	READ	ICGC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1111
p.A1587V	TCGA-E6-A1LX	UCEC	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.5825
p.A1587V	DO41020	UCEC	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.5825
p.A1587V	SIDM02030	Colorectal Carcinoma	GDSC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.5825
p.S631F	TCGA-EE-A2M5	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.0833
p.S631F	DO222423	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.0833
p.S631F	DO37425	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.0833
p.P618T	TCGA-ER-A19Q	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.7031
p.P618T	DO47497	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.7031
p.T592M	TCGA-FP-A4BF	STAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.T592M	DO50447	ESAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.T592M	DO47775	STAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0833
p.E1123K	TCGA-FR-A8YC	SKCM	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.591
p.E1123K	DO50301	SKCM	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.591
p.P1578S	TCGA-FW-A3R5	SKCM	TCGA	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.1389
p.P1578S	DO37406	SKCM	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.1389
p.E627D	TCGA-G2-AA3B	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.E627D	DO51882	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.R602W	TCGA-O1-A52J	LUAD	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.8634
p.R602W	DO218948	LUAD	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.8634
p.E1124G	TCGA-XF-A9T0	BLCA	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7199
p.E1124G	DO51920	BLCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7199
p.T1120I	TCGA-XR-A8TG	LIHC	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5966
p.T1120I	DO223924	LIHC	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5966
p.D600Y	TCGA-YC-A8S6	BLCA	TCGA	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.3056
p.D600Y	DO49806	BLCA	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.3056
p.D1129N	TCGA-ZF-A9RC	BLCA	TCGA	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1129N	DO219068	BLCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.P1128R	DO7214	CLLE	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.2222
p.A591D	DO230315	COCA	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.0556
p.V1300M	DO224689	COCA	ICGC	AVSST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0833
p.D600G	DO23192	LINC	ICGC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.3056
p.V1119I	DO231871	LINC	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.5965
p.E1124Q	DO230961	LUSC	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6744
p.E1124Q	DO224594	LUSC	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6744
p.P1128H	DO229253	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.2222
p.L1121I	DO229213	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6063
p.E1580G	DO229229	THCA	ICGC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation rewiring degron network	0.1944
p.E1580G	DO229229	THCA	ICGC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation rewiring degron network	0.0833
p.M1132I	DO229232	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1111
p.Q1131K	DO229234	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1389
p.T1120A	DO229240	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6028
p.E1115D	DO229250	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.2222
p.E1286D	SIDM02063	Colorectal Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.S1593F	SIDM00955	Melanoma	GDSC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation altering degron motif	0.7982
p.S1593F	ACH-000812	Skin Cancer	CCLE	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation altering degron motif	0.7982
p.S1593F	COLO-783	skin	COSMIC	PHTTS	DEG_SPOP_SBC_1	1589:1593	Mutation altering degron motif	0.7982
p.D1114N	SIDM00426	Rhabdomyosarcoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1114N	SIDM00214	Colorectal Carcinoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1114N	ACH-000100	Sarcoma	CCLE	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1114N	ACH-000955	Colon/Colorectal Cancer	CCLE	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1114N	ACH-001765	Sarcoma	CCLE	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1114N	RH-41	soft tissue	COSMIC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.D1114N	SNU-407	large intestine	COSMIC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1944
p.V625M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.V625M	ACH-002256	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.V625M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.N613S	SIDM01129	Small Cell Lung Carcinoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.2222
p.N613S	SIDM01129	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.T1298S	SIDM01162	Kidney Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.T1298S	ACH-001398	Kidney Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.T1298S	SW156	kidney	COSMIC	AVSST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.I1112V	SIDM00444	Esophageal Carcinoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1389
p.I1112V	OACM5-1	oesophagus	COSMIC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation rewiring degron network	0.1389
p.A1587G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.6429
p.A1587G	H513	pleura	COSMIC	VSATPHTT	DEG_SCF_FBW7_1	1585:1592	Mutation altering degron motif	0.6429
p.Y1122C	SIDM00217	Colorectal Carcinoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7087
p.Y1122C	ACH-000999	Colon/Colorectal Cancer	CCLE	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7087
p.Y1122C	SNU-1040	large intestine	COSMIC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.7087
p.Y1122F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6417
p.Y1122F	ACH-000462	Leukemia	CCLE	VTLYEE	LIG_APCC_ABBA_1	1119:1124	Mutation altering degron motif	0.6417
p.S604L	SIDM01622	Breast Carcinoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.6556
p.S604L	ACH-000721	Breast Cancer	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation altering degron motif	0.6556
p.G596V	SIDM01619	Endometrial Carcinoma	GDSC	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1944
p.G596V	ACH-000984	Endometrial/Uterine Cancer	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1944
p.H594R	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRVSLRYVW	DEG_APCC_DBOX_1	601:609	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SDK1

UniProt ID: Q7Z5N4

Entrez ID: 221935

Protein name: Protein sidekick-1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SDK1 in