DegronMD

Uniprot ID: Q7Z5N4

Source protein: Protein sidekick-1

Source gene: SDK1

Class: LIG_APCC_ABBA_1

Location: 1119:1124

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8324

ASA_SCORE: 64.75

COIL: 0.1593

CONS_SCORE: 0.3852

DSS_SCORE: 0.5073

HELIX: 0.0107

FCONS_SCORE: 0.921

RIG_SCORE: 0.8765

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1124D	TCGA-43-3920	LUSC	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.5647
p.E1124D	TCGA-AP-A059	UCEC	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.5647
p.E1124D	DO26445	LUSC	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.5647
p.E1124D	DO41361	UCEC	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.5647
p.G1113S	TCGA-49-6743	LUAD	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.1667
p.G1113S	DO26092	LUAD	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.1667
p.E1134D	TCGA-D9-A148	SKCM	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.0556
p.E1134D	DO37971	SKCM	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.0556
p.E1123K	TCGA-FR-A8YC	SKCM	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.591
p.E1123K	DO50301	SKCM	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.591
p.E1124G	TCGA-XF-A9T0	BLCA	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.7199
p.E1124G	DO51920	BLCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.7199
p.T1120I	TCGA-XR-A8TG	LIHC	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.5966
p.T1120I	DO223924	LIHC	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.5966
p.D1129N	TCGA-ZF-A9RC	BLCA	TCGA	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1129N	DO219068	BLCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.P1128R	DO7214	CLLE	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.2222
p.V1119I	DO231871	LINC	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.5965
p.E1124Q	DO230961	LUSC	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.6744
p.E1124Q	DO224594	LUSC	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.6744
p.P1128H	DO229253	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.2222
p.L1121I	DO229213	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.6063
p.M1132I	DO229232	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.1111
p.Q1131K	DO229234	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.1389
p.T1120A	DO229240	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.6028
p.E1115D	DO229250	THCA	ICGC	VTLYEE	LIG_APCC_ABBA_1	0.2222
p.D1114N	SIDM00426	Rhabdomyosarcoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1114N	SIDM00214	Colorectal Carcinoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1114N	ACH-000100	Sarcoma	CCLE	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1114N	ACH-000955	Colon/Colorectal Cancer	CCLE	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1114N	ACH-001765	Sarcoma	CCLE	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1114N	RH-41	soft_tissue	COSMIC	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.D1114N	SNU-407	large_intestine	COSMIC	VTLYEE	LIG_APCC_ABBA_1	0.1944
p.I1112V	SIDM00444	Esophageal Carcinoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	0.1389
p.I1112V	OACM5-1	oesophagus	COSMIC	VTLYEE	LIG_APCC_ABBA_1	0.1389
p.Y1122C	SIDM00217	Colorectal Carcinoma	GDSC	VTLYEE	LIG_APCC_ABBA_1	0.7087
p.Y1122C	ACH-000999	Colon/Colorectal Cancer	CCLE	VTLYEE	LIG_APCC_ABBA_1	0.7087
p.Y1122C	SNU-1040	large_intestine	COSMIC	VTLYEE	LIG_APCC_ABBA_1	0.7087
p.Y1122F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	VTLYEE	LIG_APCC_ABBA_1	0.6417
p.Y1122F	ACH-000462	Leukemia	CCLE	VTLYEE	LIG_APCC_ABBA_1	0.6417

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTLYEE

Degron related mutations and impact score

Drug responses associated with SDK1 mutations

All proteins holding degron of VTLYEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5N4	Protein sidekick-1	LIG_APCC_ABBA_1	1119:1124	VTLYEE	APC,CDC20,FZR1	0.8324	More...