DegronMD

Uniprot ID: Q7Z5N4

Source protein: Protein sidekick-1

Source gene: SDK1

Class: DEG_SPOP_SBC_1

Location: 1287:1291

E3 ligase: SPOP

DEGRON score: 0.6155

ASA_SCORE: 49.24

COIL: 0.5484

CONS_SCORE: 0.4528

DSS_SCORE: 0.2767

HELIX: 0.0122

FCONS_SCORE: 0.9256

RIG_SCORE: 0.7705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1300M	DO224689	COCA	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.E1286D	SIDM02063	Colorectal Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.T1298S	SIDM01162	Kidney Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.1389
p.T1298S	ACH-001398	Kidney Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	0.1389
p.T1298S	SW156	kidney	COSMIC	AVSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons