DegronMD - P10070(GLI2)

FUNCTION: Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992, PubMed:26565916). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682, ECO:0000305|PubMed:20685856}.; FUNCTION: [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. {ECO:0000269|PubMed:18455992}.; FUNCTION: [Isoform 1]: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). {ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:9557682}.; FUNCTION: [Isoform 5]: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P120Q	TCGA-05-4427	LUAD	TCGA	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.P120Q	DO23666	LUAD	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.E112K	TCGA-12-0820	GBM	TCGA	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.0556
p.E112K	DO12838	GBM	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.0556
p.V643I	TCGA-13-0726	OV	TCGA	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.V643I	DO28373	OV	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.Y129F	TCGA-17-Z055	LUAD	TCGA	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2778
p.R644T	TCGA-44-A479	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.R644T	DO23633	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.L227M	TCGA-78-7145	LUAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.5999
p.L227M	DO26374	LUAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.5999
p.A370T	TCGA-A2-A1FW	BRCA	TCGA	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.A370T	DO2002	BRCA	ICGC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.A370T	DO233270	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.T224M	TCGA-A5-A1OF	UCEC	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.8534
p.T224M	TCGA-BR-8368	STAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.8534
p.T224M	DO47981	STAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.8534
p.T224M	DO42568	UCEC	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.8534
p.R374S	TCGA-D3-A3CE	SKCM	TCGA	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.R374S	DO37405	SKCM	ICGC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.S627N	TCGA-D3-A8GM	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.S627N	DO50288	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.S627N	ACH-001959	Bile Duct Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.25
p.R229C	TCGA-D5-6928	COAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229C	DO7776	COAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R222W	TCGA-DD-A11A	LIHC	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7523
p.R222W	DO22835	LIHC	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7523
p.R222W	SIDM01735	Biliary Tract Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7523
p.R222W	ACH-000808	Bile Duct Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7523
p.Q635L	TCGA-E7-A8O8	BLCA	TCGA	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.Q635L	DO219020	BLCA	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.V362I	TCGA-ET-A4KN	THCA	TCGA	AVSST	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.5965
p.V362I	DO39072	THCA	ICGC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.5965
p.P625L	TCGA-FS-A1Z0	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1944
p.P625L	DO37431	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1944
p.S132Y	TCGA-FU-A3HZ	CESC	TCGA	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation blocking phosphorylation signal	0.6389
p.S132Y	DO6308	CESC	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation blocking phosphorylation signal	0.6389
p.P221S	TCGA-FW-A5DY	SKCM	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6752
p.P221S	DO47257	SKCM	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6752
p.R229H	TCGA-HC-7749	PRAD	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	DO36242	PRAD	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	SIDM01943	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	SIDM00487	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	SIDM01729	Endometrial Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	ACH-000909	Endometrial/Uterine Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	ACH-000963	Colon/Colorectal Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.R229H	CCK-81	large intestine	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.3056
p.E629K	TCGA-J2-8194	LUAD	TCGA	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.E629K	DO23971	LUAD	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.R217H	TCGA-K4-A54R	BLCA	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.R217H	DO48611	BLCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.R217H	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.R217H	ACH-000662	Lung Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.A370V	TCGA-VQ-A924	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.A370V	DO51795	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.P221L	TCGA-XF-A9T8	BLCA	TCGA	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6471
p.P221L	DO51927	BLCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6471
p.P221A	DO222461	BTCA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.7503
p.R374C	DO50382	ESAD	ICGC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.T620M	DO233766	GACA	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.P118L	DO233748	GACA	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2222
p.C640F	DO228952	LICA	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.R131L	DO229028	LICA	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.2222
p.S113Y	DO50974	LICA	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.0833
p.H119Y	DO220884	MELA	ICGC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.P212L	DO222875	MELA	ICGC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.0833
p.A636V	DO229250	THCA	ICGC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2778
p.P622L	SIDM01175	Other Sarcomas	GDSC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1111
p.P622L	ACH-002309	Sarcoma	CCLE	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1111
p.P622L	SW684	soft tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1111
p.V213M	SIDM00367	Small Cell Lung Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.V213M	SIDM00556	Neuroblastoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.V213M	SIDM00836	Colorectal Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.V213M	KP-N-YN	autonomic ganglia	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.V213M	SBC-3	lung	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.1111
p.R374L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.R374L	ACH-002255	Lymphoma	CCLE	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.R374L	KARPAS-231	haematopoietic and lymphoid tissue	COSMIC	AVSST	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.A232P	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.A232P	ACH-000892	Lung Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.A232P	NCI-H1563	lung	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.H119N	SIDM00391	Plasma Cell Myeloma	GDSC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.H119N	ACH-000363	Myeloma	CCLE	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.H119N	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	VNPHME	LIG_APCC_ABBA_1	122:127	Mutation rewiring degron network	0.25
p.A232V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.A232V	ACH-000920	Leukemia	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.A232V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation rewiring degron network	0.2222
p.P225S	ACH-000501	Colon/Colorectal Cancer	CCLE	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6752
p.P225S	LS-123	large intestine	COSMIC	PRVTPRLS	DEG_SCF_FBW7_1	221:228	Mutation altering degron motif	0.6752
p.E621K	ACH-002396	Bone Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833
p.E621K	Sarc9371	bone	COSMIC	ASSTS	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0833

Kaplan plot for GLI2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLI2

UniProt ID: P10070

Entrez ID: 2736

Protein name: Zinc finger protein GLI2 (GLI family zinc finger protein 2) (Tax helper protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLI2 in