DegronMD

Uniprot ID: P10070

Source protein: Zinc finger protein GLI2

Source gene: GLI2

Class: DEG_SPOP_SBC_1

Location: 361:365

E3 ligase: SPOP

DEGRON score: 0.9871

ASA_SCORE: 86.12

COIL: 0.9024

CONS_SCORE: 0.4548

DSS_SCORE: 0.5628

HELIX: 0.082

FCONS_SCORE: 1.1826

RIG_SCORE: 0.6317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A370T	TCGA-A2-A1FW	BRCA	TCGA	AVSST	DEG_SPOP_SBC_1	0.1944
p.A370T	DO2002	BRCA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1944
p.A370T	DO233270	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1944
p.R374S	TCGA-D3-A3CE	SKCM	TCGA	AVSST	DEG_SPOP_SBC_1	0.0833
p.R374S	DO37405	SKCM	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.V362I	TCGA-ET-A4KN	THCA	TCGA	AVSST	DEG_SPOP_SBC_1	0.5965
p.V362I	DO39072	THCA	ICGC	AVSST	DEG_SPOP_SBC_1	0.5965
p.A370V	TCGA-VQ-A924	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.1944
p.A370V	DO51795	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.1944
p.R374C	DO50382	ESAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.R374L	SIDM01017	B-Lymphoblastic Leukemia	GDSC	AVSST	DEG_SPOP_SBC_1	0.0833
p.R374L	ACH-002255	Lymphoma	CCLE	AVSST	DEG_SPOP_SBC_1	0.0833
p.R374L	KARPAS-231	haematopoietic_and_lymphoid_tissue	COSMIC	AVSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons