DegronMD - Q15052(ARHGEF6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131T	TCGA-05-4422	LUAD	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.5833
p.S131T	DO25907	LUAD	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.5833
p.E740K	TCGA-56-8622	LUSC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.1944
p.E740K	TCGA-DU-6392	LGG	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.1944
p.L749I	TCGA-60-2695	LUSC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7174
p.A138E	TCGA-73-4670	LUAD	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7701
p.A138E	TCGA-Y8-A8S1	KIRP	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7701
p.A138E	DO51574	KIRP	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7701
p.A138E	DO25350	LUAD	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7701
p.Q136H	TCGA-AP-A059	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.R754W	TCGA-AP-A0LM	UCEC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.3056
p.Q136E	TCGA-AQ-A1H3	BRCA	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.Q136E	DO1668	BRCA	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.E741D	TCGA-CA-6717	COAD	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.2222
p.R754Q	TCGA-CG-4460	STAD	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.3056
p.G137E	TCGA-CW-5587	KIRC	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.G137E	DO19430	KIRC	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.E742K	TCGA-DH-A66G	LGG	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.E742K	TCGA-E9-A295	BRCA	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.K151N	TCGA-DX-A48L	SARC	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking ubiquitination signal	0.5278
p.K151N	DO219985	SARC	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking ubiquitination signal	0.5278
p.L146R	TCGA-EO-A22R	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2222
p.L146R	DO42713	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2222
p.R746K	TCGA-EO-A3AV	UCEC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.7237
p.V753L	TCGA-MP-A4T4	LUAD	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation altering degron motif	0.5654
p.N129T	TCGA-ND-A4WC	UCS	TCGA	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833
p.T152N	DO8240	COAD	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.T133K	DO229022	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.6389
p.T144K	DO229031	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.7222
p.T142K	DO229041	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7306
p.E136Q	DO29218	OV	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.G133R	DO42256	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.6389
p.L131S	DO41133	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation blocking phosphorylation signal	0.5833
p.E762A	SIDM02053	Colorectal Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.0833
p.L739M	SIDM00878	Breast Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.1667
p.T152I	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.T152I	ACH-000309	Lung Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.T152I	SK-LU-1	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.E742Q	SIDM00905	Cervical Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.E742Q	ACH-001334	Cervical Cancer	CCLE	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.E742Q	ACH-001335	Cervical Cancer	CCLE	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.E742Q	C-4-I	cervix	COSMIC	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.L756F	SIDM01140	Ovarian Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.L756F	ACH-001374	Ovarian Cancer	CCLE	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.L756F	PA-1	ovary	COSMIC	SRRDLEKLV	DEG_APCC_DBOX_1	745:753	Mutation rewiring degron network	0.25
p.N129D	ACH-001194	Kidney Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF6

UniProt ID: Q15052

Entrez ID: 9459

Protein name: Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF6 in