DegronMD

Uniprot ID: Q15052

Source protein: Rho guanine nucleotide exchange factor 6

Source gene: ARHGEF6

Class: DEG_APCC_DBOX_1

Location: 745:753

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7217

ASA_SCORE: 80.8222

COIL: 0.0268

CONS_SCORE: 0.4449

DSS_SCORE: 0.2607

HELIX: 0.9738

FCONS_SCORE: 1.1723

RIG_SCORE: 0.8112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E740K	TCGA-56-8622	LUSC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.1944
p.E740K	TCGA-DU-6392	LGG	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.1944
p.L749I	TCGA-60-2695	LUSC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.7174
p.R754W	TCGA-AP-A0LM	UCEC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.3056
p.E741D	TCGA-CA-6717	COAD	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.2222
p.R754Q	TCGA-CG-4460	STAD	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.3056
p.E742K	TCGA-DH-A66G	LGG	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.E742K	TCGA-E9-A295	BRCA	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.R746K	TCGA-EO-A3AV	UCEC	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.7237
p.V753L	TCGA-MP-A4T4	LUAD	TCGA	SRRDLEKLV	DEG_APCC_DBOX_1	0.5654
p.E762A	SIDM02053	Colorectal Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	0.0833
p.L739M	SIDM00878	Breast Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	0.1667
p.E742Q	SIDM00905	Cervical Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.E742Q	ACH-001334	Cervical Cancer	CCLE	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.E742Q	ACH-001335	Cervical Cancer	CCLE	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.E742Q	C-4-I	cervix	COSMIC	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.L756F	SIDM01140	Ovarian Carcinoma	GDSC	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.L756F	ACH-001374	Ovarian Cancer	CCLE	SRRDLEKLV	DEG_APCC_DBOX_1	0.25
p.L756F	PA-1	ovary	COSMIC	SRRDLEKLV	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15052	Rho guanine nucleotide exchange factor 6	DEG_APCC_DBOX_1	745:753	SRRDLEKLV	APC,CDC20,FZR1	0.7217	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons