DegronMD

Uniprot ID: Q15052

Source protein: Rho guanine nucleotide exchange factor 6

Source gene: ARHGEF6

Class: DEG_SPOP_SBC_1

Location: 138:142

E3 ligase: SPOP

DEGRON score: 0.9973

ASA_SCORE: 63.5

COIL: 0.7652

CONS_SCORE: 0.3003

DSS_SCORE: 0.6326

HELIX: 0.0678

FCONS_SCORE: 1.0035

RIG_SCORE: 0.6607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S131T	TCGA-05-4422	LUAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.5833
p.S131T	DO25907	LUAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.5833
p.A138E	TCGA-73-4670	LUAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.7701
p.A138E	TCGA-Y8-A8S1	KIRP	TCGA	AVSST	DEG_SPOP_SBC_1	0.7701
p.A138E	DO51574	KIRP	ICGC	AVSST	DEG_SPOP_SBC_1	0.7701
p.A138E	DO25350	LUAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.7701
p.Q136H	TCGA-AP-A059	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	0.2778
p.Q136E	TCGA-AQ-A1H3	BRCA	TCGA	AVSST	DEG_SPOP_SBC_1	0.2778
p.Q136E	DO1668	BRCA	ICGC	AVSST	DEG_SPOP_SBC_1	0.2778
p.G137E	TCGA-CW-5587	KIRC	TCGA	AVSST	DEG_SPOP_SBC_1	0.3056
p.G137E	DO19430	KIRC	ICGC	AVSST	DEG_SPOP_SBC_1	0.3056
p.K151N	TCGA-DX-A48L	SARC	TCGA	AVSST	DEG_SPOP_SBC_1	0.5278
p.K151N	DO219985	SARC	ICGC	AVSST	DEG_SPOP_SBC_1	0.5278
p.L146R	TCGA-EO-A22R	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	0.2222
p.L146R	DO42713	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	0.2222
p.N129T	TCGA-ND-A4WC	UCS	TCGA	AVSST	DEG_SPOP_SBC_1	0.0833
p.T152N	DO8240	COAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.0556
p.T133K	DO229022	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.6389
p.T144K	DO229031	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.7222
p.T142K	DO229041	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.7306
p.E136Q	DO29218	OV	ICGC	AVSST	DEG_SPOP_SBC_1	0.2778
p.G133R	DO42256	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	0.6389
p.L131S	DO41133	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	0.5833
p.T152I	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.0556
p.T152I	ACH-000309	Lung Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	0.0556
p.T152I	SK-LU-1	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.0556
p.N129D	ACH-001194	Kidney Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons