DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AVSST
Uniprot ID:
Q6AI39
Source protein:
BRD4-interacting chromatin-remodeling complex-associated protein-like
Source gene:
BICRAL
Class:
DEG_SPOP_SBC_1
Location:
377:381
E3 ligase:
SPOP
DEGRON score:
0.9866
ASA_SCORE:
80.14
COIL:
0.8914
CONS_SCORE:
0.7195
DSS_SCORE:
0.524
HELIX:
0.03
FCONS_SCORE:
1.1472
RIG_SCORE:
0.6481
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with BICRAL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AVSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P10070
Zinc finger protein GLI2
DEG_SPOP_SBC_1
361:365
AVSST
SPOP
0.9871
More...
P10071
Transcriptional activator GLI3
DEG_SPOP_SBC_1
422:426
AVSST
SPOP
0.971
More...
P10914
Interferon regulatory factor 1
DEG_SPOP_SBC_1
187:191
AVSST
SPOP
0.9982
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1756:1760
AVSST
SPOP
0.8694
More...
Q15052
Rho guanine nucleotide exchange factor 6
DEG_SPOP_SBC_1
138:142
AVSST
SPOP
0.9973
More...
Q6AI39
BRD4-interacting chromatin-remodeling complex-associated protein-like
DEG_SPOP_SBC_1
377:381
AVSST
SPOP
0.9866
More...
Q7Z5N4
Protein sidekick-1
DEG_SPOP_SBC_1
1287:1291
AVSST
SPOP
0.6155
More...
Q92547
DNA topoisomerase 2-binding protein 1
DEG_SPOP_SBC_1
1017:1021
AVSST
SPOP
0.9996
More...
Q9BX66
Sorbin and SH3 domain-containing protein 1
DEG_SPOP_SBC_1
266:270
AVSST
SPOP
0.99
More...
Q9GZV5
WW domain-containing transcription regulator protein 1
DEG_SPOP_SBC_1
171:175
AVSST
SPOP
0.9911
More...