DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 1756:1760

E3 ligase: SPOP

DEGRON score: 0.8694

ASA_SCORE: 85.7

COIL: 0.907

CONS_SCORE: 0.6768

DSS_SCORE: 0.4282

HELIX: 0.0098

FCONS_SCORE: 1.0401

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1761S	SIDM01164	Glioma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.P1761S	SIDM01041	Esophageal Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.P1761S	SIDM00813	Non-Cancerous	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.P1761S	SIDM00518	Mesothelioma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.P1761S	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.P1761S	SIDM00335	Endometrial Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.S1759C	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons