DegronMD

Uniprot ID: P10071

Source protein: Transcriptional activator GLI3

Source gene: GLI3

Class: DEG_SPOP_SBC_1

Location: 422:426

E3 ligase: SPOP

DEGRON score: 0.971

ASA_SCORE: 65.18

COIL: 0.8878

CONS_SCORE: 0.5546

DSS_SCORE: 0.7967

HELIX: 0.043

FCONS_SCORE: 1.3128

RIG_SCORE: 0.5477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P429L	TCGA-AA-3815	COAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.25
p.P429L	DO9924	COAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.25
p.P429L	SIDM01962	Colorectal Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.25
p.D428N	DO222541	BTCA	ICGC	AVSST	DEG_SPOP_SBC_1	0.2778
p.T418S	DO233134	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	0.2222
p.K436T	DO233107	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1667
p.P417T	DO228952	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1944
p.N415K	DO229041	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1389
p.S435Y	DO45139	LIRI	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.T418M	DO30060	OV	ICGC	AVSST	DEG_SPOP_SBC_1	0.2222
p.S421F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.3056
p.S421F	ACH-000951	Lung Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	0.3056
p.S421F	NCI-H2342	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons