DegronMD - Q9GZV5(WWTR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q161E	TCGA-36-2551	OV	TCGA	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.Q161E	DO28036	OV	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0556
p.V177L	TCGA-55-8510	LUAD	TCGA	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.V177L	DO24339	LUAD	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2778
p.A183S	TCGA-85-8352	LUSC	TCGA	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.A183S	DO45540	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.V172I	TCGA-BR-6802	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.5965
p.V172I	DO38332	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation altering degron motif	0.5965
p.P178S	TCGA-EE-A2MJ	SKCM	TCGA	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.25
p.P178S	DO38099	SKCM	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.25
p.K54E	TCGA-GF-A3OT	SKCM	TCGA	DSGSHS	DEG_SCF_TRCP1_1	57:62	Mutation substituting flanking lysine	0.3611
p.K54E	DO47288	SKCM	ICGC	DSGSHS	DEG_SCF_TRCP1_1	57:62	Mutation substituting flanking lysine	0.3611
p.Q179H	TCGA-XF-AAMX	BLCA	TCGA	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.Q179H	DO51939	BLCA	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.2222
p.P176T	DO228952	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.3056
p.P162A	DO46483	OV	ICGC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.0833
p.M182V	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1389
p.G72C	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	DSGSHS	DEG_SCF_TRCP1_1	57:62	Mutation rewiring degron network	0.0556
p.G72C	ACH-000447	Lung Cancer	CCLE	DSGSHS	DEG_SCF_TRCP1_1	57:62	Mutation rewiring degron network	0.0556
p.A183V	SIDM00153	T-Lymphoblastic Leukemia	GDSC	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.A183V	ACH-000964	Leukemia	CCLE	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1111
p.M166V	ACH-001786	Colon/Colorectal Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	171:175	Mutation rewiring degron network	0.1944

Kaplan plot for WWTR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WWTR1

UniProt ID: Q9GZV5

Entrez ID: 25937

Protein name: WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WWTR1 in