DegronMD

Uniprot ID: Q9GZV5

Source protein: WW domain-containing transcription regulator protein 1

Source gene: WWTR1

Class: DEG_SPOP_SBC_1

Location: 171:175

E3 ligase: SPOP

DEGRON score: 0.9911

ASA_SCORE: 83.76

COIL: 0.9264

CONS_SCORE: 0.3491

DSS_SCORE: 0.6113

HELIX: 0.0424

FCONS_SCORE: 0.8791

RIG_SCORE: 0.6241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q161E	TCGA-36-2551	OV	TCGA	AVSST	DEG_SPOP_SBC_1	0.0556
p.Q161E	DO28036	OV	ICGC	AVSST	DEG_SPOP_SBC_1	0.0556
p.V177L	TCGA-55-8510	LUAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.2778
p.V177L	DO24339	LUAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.2778
p.A183S	TCGA-85-8352	LUSC	TCGA	AVSST	DEG_SPOP_SBC_1	0.1111
p.A183S	DO45540	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	0.1111
p.V172I	TCGA-BR-6802	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.5965
p.V172I	DO38332	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.5965
p.P178S	TCGA-EE-A2MJ	SKCM	TCGA	AVSST	DEG_SPOP_SBC_1	0.25
p.P178S	DO38099	SKCM	ICGC	AVSST	DEG_SPOP_SBC_1	0.25
p.Q179H	TCGA-XF-AAMX	BLCA	TCGA	AVSST	DEG_SPOP_SBC_1	0.2222
p.Q179H	DO51939	BLCA	ICGC	AVSST	DEG_SPOP_SBC_1	0.2222
p.P176T	DO228952	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.3056
p.P162A	DO46483	OV	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.M182V	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.1389
p.A183V	SIDM00153	T-Lymphoblastic Leukemia	GDSC	AVSST	DEG_SPOP_SBC_1	0.1111
p.A183V	ACH-000964	Leukemia	CCLE	AVSST	DEG_SPOP_SBC_1	0.1111
p.M166V	ACH-001786	Colon/Colorectal Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons