DegronMD - Q9BX66(SORBS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1164H	TCGA-50-6590	LUAD	TCGA	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.1944
p.Q1164E	TCGA-55-8507	LUAD	TCGA	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.1944
p.R256H	TCGA-AX-A0J1	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.R256H	DO41199	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.A502T	TCGA-AX-A1CE	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7139
p.A976S	TCGA-B5-A11E	UCEC	TCGA	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1111
p.A976S	DO41644	UCEC	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1111
p.S259L	TCGA-BR-8363	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.5833
p.S259L	DO47837	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.5833
p.S269C	TCGA-CR-7389	HNSC	TCGA	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7541
p.S269C	DO14190	HNSC	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7541
p.R256C	TCGA-CV-5436	HNSC	TCGA	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.R256C	DO15006	HNSC	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.R974S	TCGA-D3-A2JL	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1667
p.R974S	DO47278	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1667
p.P967L	TCGA-D3-A5GL	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.6471
p.P967L	TCGA-ER-A199	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.6471
p.P967L	DO47430	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.6471
p.P967L	DO47395	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.6471
p.R257T	TCGA-DR-A0ZM	CESC	TCGA	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0833
p.R257T	DO6254	CESC	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0833
p.A638V	TCGA-EB-A6QY	SKCM	TCGA	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.3056
p.S957F	TCGA-EE-A2MD	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.S957F	DO222434	MELA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.S957F	DO37851	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.P1177L	TCGA-EE-A3J7	SKCM	TCGA	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.2778
p.S655Y	TCGA-F5-6814	READ	TCGA	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0833
p.R503C	TCGA-FW-A3R5	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.719
p.R975Q	TCGA-L5-A43J	ESCA	TCGA	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1389
p.S1161R	TCGA-NC-A5HL	LUSC	TCGA	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.1111
p.G265R	TCGA-NC-A5HN	LUSC	TCGA	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.G265R	DO52025	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.R1176Q	TCGA-VQ-A8E3	STAD	TCGA	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.3056
p.E1166K	DO51884	BLCA	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.25
p.E1166K	DO51468	PACA	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.25
p.P1170Q	DO9956	COAD	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7035
p.A516V	DO230342	COCA	ICGC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.A516V	ACH-000943	Colon/Colorectal Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.A516V	RKO	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.Y937F	DO52453	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation blocking phosphorylation signal	0.6667
p.S960G	DO228123	EOPC	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.2778
p.P1179T	DO11956	GBM	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation substituting flanking lysine	0.3333
p.P960T	DO228948	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.2778
p.S500R	DO228978	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2778
p.P966T	DO228971	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.7031
p.P142T	DO229028	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.P142T	DO229038	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.N957K	DO229034	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.N957K	DO229008	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.L964M	DO229034	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.711
p.S953R	DO229034	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation blocking phosphorylation signal	0.5278
p.S953R	DO229034	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation blocking phosphorylation signal	0.5556
p.S978Y	DO229038	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.0556
p.P965T	DO229041	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.7031
p.S634F	DO229048	LICA	ICGC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.1944
p.S973L	DO229054	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.S973L	DO51280	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.T1172K	DO25280	LUAD	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7306
p.P148S	DO51195	LUAD	ICGC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.P148S	huH-1	liver	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.3056
p.V280L	DO219209	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.R267C	DO220910	MELA	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.8301
p.V1183M	DO35345	PACA	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation blocking phosphorylation signal	0.5556
p.V1183M	DO42161	UCEC	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation blocking phosphorylation signal	0.5556
p.R495Q	DO232761	PBCA	ICGC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation blocking phosphorylation signal	0.5833
p.N959S	DO232761	PBCA	ICGC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.25
p.V947M	DO232555	PBCA	ICGC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation blocking phosphorylation signal	0.7222
p.S270T	DO37372	READ	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7116
p.L263I	DO37410	SKCM	ICGC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.25
p.P1170L	DO51785	STAD	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7582
p.R163Q	DO43306	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0556
p.R163Q	DO41379	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0556
p.R1174Q	DO223286	UCEC	ICGC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7329
p.A149T	SIDM02042	Pancreatic Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.7139
p.S151T	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6005
p.S151T	SIDM01693	B-Lymphoblastic Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6005
p.P157S	SIDM00586	Hepatocellular Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157S	ACH-000475	Liver Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.P157S	huH-1	liver	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.R1174S	SIDM00845	Burkitt's Lymphoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7427
p.R1174S	SIDM01519	Head and Neck Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7427
p.R1174S	Daudi	haematopoietic and lymphoid tissue	COSMIC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7427
p.R503H	SIDM00781	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7133
p.R503H	ACH-001199	Colon/Colorectal Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7133
p.R503H	SNU-C2B	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7133
p.H1170Q	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7582
p.H1170Q	HCC-44	lung	COSMIC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7582
p.S973F	SIDM01175	Other Sarcomas	GDSC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.S973F	ACH-002309	Sarcoma	CCLE	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.S973F	SW684	soft tissue	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1944
p.S1169F	SIDM00351	Oral Cavity Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7982
p.S1169F	SAS	upper aerodigestive tract	COSMIC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.7982
p.Y937C	SIDM01045	Endometrial Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation blocking phosphorylation signal	0.6667
p.Y937C	ACH-000978	Endometrial/Uterine Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation blocking phosphorylation signal	0.6667
p.Y937C	EN	endometrium	COSMIC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation blocking phosphorylation signal	0.6667
p.S944Y	SIDM00905	Cervical Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.712
p.S944Y	ACH-001334	Cervical Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.712
p.S944Y	ACH-001335	Cervical Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.712
p.S944Y	C-4-I	cervix	COSMIC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.712
p.P629L	SIDM00489	Oral Cavity Carcinoma	GDSC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0556
p.P629L	ACH-002043	Head and Neck Cancer	CCLE	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0556
p.P629L	Ca9-22	upper aerodigestive tract	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0556
p.V162A	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.V162A	ACH-000785	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.V162A	NCI-H2126	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.0833
p.S958N	SIDM00179	Melanoma	GDSC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.2222
p.S958N	ACH-002165	Skin Cancer	CCLE	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.2222
p.S958N	MZ2-MEL	skin	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.2222
p.S943F	SIDM01695	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.9093
p.S943F	ACH-000166	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation altering degron motif	0.9093
p.S1185N	SIDM01519	Head and Neck Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.0556
p.R648W	ACH-000847	Gastric Cancer	CCLE	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.2778
p.R648W	HGC-27	stomach	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.2778
p.A502V	ACH-000958	Colon/Colorectal Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.5825
p.A502V	SW48	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.5825
p.S494G	ACH-000988	Endometrial/Uterine Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1111
p.S494G	MFE-319	endometrium	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1111
p.P948S	ACH-000997	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.25
p.P948S	HCT-15	large intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.25
p.Q1164K	ACH-001518	Endometrial/Uterine Cancer	CCLE	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.1944
p.P512L	ACH-001550	Skin Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1667
p.P512L	MCC13	skin	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1667
p.S1183G	ACH-001664	Gastric Cancer	CCLE	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation blocking phosphorylation signal	0.5556
p.G637R	DMS-53	lung	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.2778
p.L1168P	Daudi	haematopoietic and lymphoid tissue	COSMIC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation rewiring degron network	0.3056
p.Y952H	PF-382	haematopoietic and lymphoid tissue	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.0556
p.Y952H	PF-382	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation rewiring degron network	0.1389
p.R499C	Sarc9371	bone	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.25
p.K649R	DU-145	prostate	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.25
p.L159V	HT-115	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1667
p.T646M	COLO-320-HSR	large intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation altering degron motif	0.7423
p.T646M	CAKI-1	kidney	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation altering degron motif	0.7423
p.P932S	COLO-792	skin	COSMIC	PFSSS	DEG_SPOP_SBC_1	941:945	Mutation substituting flanking lysine	0.1944
p.R157H	SNU-1040	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2222
p.S966Y	C-4-I	cervix	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.712
p.D258Y	NCI-H1734	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.A145V	SNU-C2B	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation substituting flanking lysine	0.3333
p.T278N	SNU-1040	large intestine	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.I508T	FADU	upper aerodigestive tract	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2778
p.Q270H	NCI-H1651	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7582
p.T643A	SNU-C5	large intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation altering degron motif	0.7139
p.S264L	BICR22	upper aerodigestive tract	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.7222
p.H515R	AN3-CA	endometrium	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.A158T	HCC1954	breast	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1944
p.S264A	SNU-81	large intestine	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.7222
p.P651L	Ca9-22	upper aerodigestive tract	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.1944
p.T155N	SNU-1040	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.Y959C	EN	endometrium	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.25
p.I276T	FADU	upper aerodigestive tract	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.P1170S	COLO-792	skin	COSMIC	LNTPEES	DEG_SCF_FBW7_1	1169:1175	Mutation altering degron motif	0.6752
p.A268T	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7139
p.H629R	SW620	large intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0556
p.H629R	HH	haematopoietic and lymphoid tissue	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0556
p.P963L	JHH-7	liver	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation altering degron motif	0.7582
p.T160A	NCI-H446	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.1389
p.D268Y	NCI-H1734	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7325
p.A976T	SNU-1040	large intestine	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.1111
p.T511A	SNU-C5	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.A145T	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation substituting flanking lysine	0.3333
p.L150V	HT-115	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6765
p.Y632H	PF-382	haematopoietic and lymphoid tissue	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.1389
p.E155A	KATOIII	stomach	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation rewiring degron network	0.2778
p.F655C	HCC2998	large intestine	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation rewiring degron network	0.0833
p.L977F	NB14	autonomic ganglia	COSMIC	LITPAPS	DEG_SCF_FBW7_1	962:968	Mutation rewiring degron network	0.0833
p.S502Y	PCI-6A	upper aerodigestive tract	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.712
p.V153A	NCI-H2126	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation altering degron motif	0.6936
p.S642F	Sarc9371	bone	COSMIC	ISPTPEIS	DEG_SCF_FBW7_1	639:646	Mutation altering degron motif	0.7982
p.D271Y	NCI-H1651	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.G505R	DMS-53	lung	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation altering degron motif	0.7568
p.T146N	SNU-1040	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	149:153	Mutation blocking phosphorylation signal	0.6944
p.R507H	CL-40	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.3056
p.I275T	FADU	upper aerodigestive tract	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.D259Y	NCI-H1734	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation blocking phosphorylation signal	0.5833
p.K278N	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	AVSST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SORBS1

UniProt ID: Q9BX66

Entrez ID: 10580

Protein name: Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SORBS1 in