DegronMD

Uniprot ID: Q9BX66

Source protein: Sorbin and SH3 domain-containing protein 1

Source gene: SORBS1

Class: DEG_SCF_FBW7_1

Location: 1169:1175

E3 ligase: FBXW7

DEGRON score: 0.8674

ASA_SCORE: 92.2857

COIL: 0.8936

CONS_SCORE: 0.1053

DSS_SCORE: 0.7076

HELIX: 0.0783

FCONS_SCORE: 1

RIG_SCORE: 0.6358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1164H	TCGA-50-6590	LUAD	TCGA	LNTPEES	DEG_SCF_FBW7_1	0.1944
p.Q1164E	TCGA-55-8507	LUAD	TCGA	LNTPEES	DEG_SCF_FBW7_1	0.1944
p.P1177L	TCGA-EE-A3J7	SKCM	TCGA	LNTPEES	DEG_SCF_FBW7_1	0.2778
p.S1161R	TCGA-NC-A5HL	LUSC	TCGA	LNTPEES	DEG_SCF_FBW7_1	0.1111
p.R1176Q	TCGA-VQ-A8E3	STAD	TCGA	LNTPEES	DEG_SCF_FBW7_1	0.3056
p.E1166K	DO51884	BLCA	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.25
p.E1166K	DO51468	PACA	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.25
p.P1170Q	DO9956	COAD	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.7035
p.P1179T	DO11956	GBM	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.3333
p.T1172K	DO25280	LUAD	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.7306
p.V1183M	DO35345	PACA	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.5556
p.V1183M	DO42161	UCEC	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.5556
p.P1170L	DO51785	STAD	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.7582
p.R1174Q	DO223286	UCEC	ICGC	LNTPEES	DEG_SCF_FBW7_1	0.7329
p.R1174S	SIDM00845	Burkitt's Lymphoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	0.7427
p.R1174S	SIDM01519	Head and Neck Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	0.7427
p.R1174S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LNTPEES	DEG_SCF_FBW7_1	0.7427
p.H1170Q	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	0.7582
p.H1170Q	HCC-44	lung	COSMIC	LNTPEES	DEG_SCF_FBW7_1	0.7582
p.S1169F	SIDM00351	Oral Cavity Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	0.7982
p.S1169F	SAS	upper_aerodigestive_tract	COSMIC	LNTPEES	DEG_SCF_FBW7_1	0.7982
p.S1185N	SIDM01519	Head and Neck Carcinoma	GDSC	LNTPEES	DEG_SCF_FBW7_1	0.0556
p.Q1164K	ACH-001518	Endometrial/Uterine Cancer	CCLE	LNTPEES	DEG_SCF_FBW7_1	0.1944
p.S1183G	ACH-001664	Gastric Cancer	CCLE	LNTPEES	DEG_SCF_FBW7_1	0.5556
p.L1168P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	LNTPEES	DEG_SCF_FBW7_1	0.3056
p.P1170S	COLO-792	skin	COSMIC	LNTPEES	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SCF_FBW7_1	1169:1175	LNTPEES	FBXW7	0.8674	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNTPEES

Degron related mutations and impact score

Drug responses associated with SORBS1 mutations

All proteins holding degron of LNTPEES