DegronMD

Uniprot ID: Q9BX66

Source protein: Sorbin and SH3 domain-containing protein 1

Source gene: SORBS1

Class: DEG_SCF_FBW7_1

Location: 962:968

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 96.4

COIL: 0.9676

CONS_SCORE: 0.1226

DSS_SCORE: 0.5562

HELIX: 0.0131

FCONS_SCORE: 0.6391

RIG_SCORE: 0.6153

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A976S	TCGA-B5-A11E	UCEC	TCGA	LITPAPS	DEG_SCF_FBW7_1	0.1111
p.A976S	DO41644	UCEC	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1111
p.R974S	TCGA-D3-A2JL	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	0.1667
p.R974S	DO47278	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1667
p.P967L	TCGA-D3-A5GL	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	0.6471
p.P967L	TCGA-ER-A199	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	0.6471
p.P967L	DO47430	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.6471
p.P967L	DO47395	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.6471
p.S957F	TCGA-EE-A2MD	SKCM	TCGA	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.S957F	DO222434	MELA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.S957F	DO37851	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.R975Q	TCGA-L5-A43J	ESCA	TCGA	LITPAPS	DEG_SCF_FBW7_1	0.1389
p.S960G	DO228123	EOPC	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.2778
p.P960T	DO228948	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.2778
p.P966T	DO228971	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.7031
p.N957K	DO229034	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.N957K	DO229008	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.L964M	DO229034	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.711
p.S953R	DO229034	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.5278
p.S978Y	DO229038	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.0556
p.P965T	DO229041	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.7031
p.S973L	DO229054	LICA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.S973L	DO51280	SKCM	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.N959S	DO232761	PBCA	ICGC	LITPAPS	DEG_SCF_FBW7_1	0.25
p.S973F	SIDM01175	Other Sarcomas	GDSC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.S973F	ACH-002309	Sarcoma	CCLE	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.S973F	SW684	soft_tissue	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.1944
p.S958N	SIDM00179	Melanoma	GDSC	LITPAPS	DEG_SCF_FBW7_1	0.2222
p.S958N	ACH-002165	Skin Cancer	CCLE	LITPAPS	DEG_SCF_FBW7_1	0.2222
p.S958N	MZ2-MEL	skin	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.2222
p.Y952H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.0556
p.S966Y	C-4-I	cervix	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.712
p.Y959C	EN	endometrium	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.25
p.P963L	JHH-7	liver	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.7582
p.A976T	SNU-1040	large_intestine	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.1111
p.L977F	NB14	autonomic_ganglia	COSMIC	LITPAPS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LITPAPS

Degron related mutations and impact score

Drug responses associated with SORBS1 mutations

All proteins holding degron of LITPAPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SCF_FBW7_1	962:968	LITPAPS	FBXW7	0.9973	More...