DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PFSSS
Uniprot ID:
Q9BX66
Source protein:
Sorbin and SH3 domain-containing protein 1
Source gene:
SORBS1
Class:
DEG_SPOP_SBC_1
Location:
941:945
E3 ligase:
SPOP
DEGRON score:
0.9991
ASA_SCORE:
74.32
COIL:
0.9218
CONS_SCORE:
0.5207
DSS_SCORE:
0.4294
HELIX:
0.0368
FCONS_SCORE:
1.1723
RIG_SCORE:
0.6949
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y937F
DO52453
COCA
ICGC
PFSSS
DEG_SPOP_SBC_1
0.6667
p.S953R
DO229034
LICA
ICGC
PFSSS
DEG_SPOP_SBC_1
0.5556
p.V947M
DO232555
PBCA
ICGC
PFSSS
DEG_SPOP_SBC_1
0.7222
p.Y937C
SIDM01045
Endometrial Carcinoma
GDSC
PFSSS
DEG_SPOP_SBC_1
0.6667
p.Y937C
ACH-000978
Endometrial/Uterine Cancer
CCLE
PFSSS
DEG_SPOP_SBC_1
0.6667
p.Y937C
EN
endometrium
COSMIC
PFSSS
DEG_SPOP_SBC_1
0.6667
p.S944Y
SIDM00905
Cervical Carcinoma
GDSC
PFSSS
DEG_SPOP_SBC_1
0.712
p.S944Y
ACH-001334
Cervical Cancer
CCLE
PFSSS
DEG_SPOP_SBC_1
0.712
p.S944Y
ACH-001335
Cervical Cancer
CCLE
PFSSS
DEG_SPOP_SBC_1
0.712
p.S944Y
C-4-I
cervix
COSMIC
PFSSS
DEG_SPOP_SBC_1
0.712
p.S943F
SIDM01695
Acute Myeloid Leukemia
GDSC
PFSSS
DEG_SPOP_SBC_1
0.9093
p.S943F
ACH-000166
Leukemia
CCLE
PFSSS
DEG_SPOP_SBC_1
0.9093
p.P948S
ACH-000997
Colon/Colorectal Cancer
CCLE
PFSSS
DEG_SPOP_SBC_1
0.25
p.P948S
HCT-15
large_intestine
COSMIC
PFSSS
DEG_SPOP_SBC_1
0.25
p.Y952H
PF-382
haematopoietic_and_lymphoid_tissue
COSMIC
PFSSS
DEG_SPOP_SBC_1
0.1389
p.P932S
COLO-792
skin
COSMIC
PFSSS
DEG_SPOP_SBC_1
0.1944
Drug responses associated with SORBS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PFSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14526
F-BAR domain only protein 1
DEG_SPOP_SBC_1
463:467
PFSSS
SPOP
0.7117
More...
O14686
Histone-lysine N-methyltransferase 2D
DEG_SPOP_SBC_1
3172:3176
PFSSS
SPOP
0.987
More...
O15049
NEDD4-binding protein 3
DEG_SPOP_SBC_1
207:211
PFSSS
SPOP
0.9962
More...
O43294
Transforming growth factor beta-1-induced transcript 1 protein
DEG_SPOP_SBC_1
78:82
PFSSS
SPOP
0.9307
More...
O75385
Serine/threonine-protein kinase ULK1
DEG_SPOP_SBC_1
420:424
PFSSS
SPOP
0.9904
More...
O75916
Regulator of G-protein signaling 9
DEG_SPOP_SBC_1
495:499
PFSSS
SPOP
0.9118
More...
P16333
Cytoplasmic protein NCK1
DEG_SPOP_SBC_1
200:204
PFSSS
SPOP
0.8259
More...
P25054
Adenomatous polyposis coli protein
DEG_SPOP_SBC_1
2761:2765
PFSSS
SPOP
0.996
More...
P33076
MHC class II transactivator
DEG_SPOP_SBC_1
211:215
PFSSS
SPOP
0.9232
More...
P98082
Disabled homolog 2
DEG_SPOP_SBC_1
365:369
PFSSS
SPOP
0.9901
More...
Q03164
Histone-lysine N-methyltransferase 2A
DEG_SPOP_SBC_1
826:830
PFSSS
SPOP
0.929
More...
Q3SXY7
Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3
DEG_SPOP_SBC_1
414:418
PFSSS
SPOP
0.7392
More...
Q5T011
KICSTOR complex protein SZT2
DEG_SPOP_SBC_1
1367:1371
PFSSS
SPOP
0.6184
More...
Q68DE3
Basic helix-loop-helix domain-containing protein USF3
DEG_SPOP_SBC_1
1896:1900
PFSSS
SPOP
0.9564
More...
Q6RI45
Bromodomain and WD repeat-containing protein 3
DEG_SPOP_SBC_1
1518:1522
PFSSS
SPOP
0.8389
More...
Q8IZP9
Adhesion G-protein coupled receptor G2
DEG_SPOP_SBC_1
254:258
PFSSS
SPOP
0.786
More...
Q8N6G6
ADAMTS-like protein 1
DEG_SPOP_SBC_1
836:840
PFSSS
SPOP
0.7453
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
10331:10335
PFSSS
SPOP
0.9441
More...
Q96J92
Serine/threonine-protein kinase WNK4
DEG_SPOP_SBC_1
864:868
PFSSS
SPOP
0.8261
More...
Q9BX66
Sorbin and SH3 domain-containing protein 1
DEG_SPOP_SBC_1
941:945
PFSSS
SPOP
0.9991
More...
Q9BYP7
Serine/threonine-protein kinase WNK3
DEG_SPOP_SBC_1
1144:1148
PFSSS
SPOP
0.938
More...
Q9HAK2
Transcription factor COE2
DEG_SPOP_SBC_1
527:531
PFSSS
SPOP
0.7804
More...
Q9NX40
OCIA domain-containing protein 1
DEG_SPOP_SBC_1
163:167
PFSSS
SPOP
0.9989
More...
Q9UBC2
Epidermal growth factor receptor substrate 15-like 1
DEG_SPOP_SBC_1
710:714
PFSSS
SPOP
0.9988
More...
Q9UQR0
Sex comb on midleg-like protein 2
DEG_SPOP_SBC_1
466:470
PFSSS
SPOP
0.9364
More...
Q86W28
NACHT, LRR and PYD domains-containing protein 8
DEG_SPOP_SBC_1
13:17
PFSSS
SPOP
0.9844
More...
Q8NDH2
Leucine-rich repeat transmembrane protein CCDC168
DEG_SPOP_SBC_1
350:354
PFSSS
SPOP
0.9972
More...
Q92545
Transmembrane protein 131
DEG_SPOP_SBC_1
1803:1807
PFSSS
SPOP
0.6327
More...
Q9ULL1
Pleckstrin homology domain-containing family G member 1
DEG_SPOP_SBC_1
61:65
PFSSS
SPOP
0.9867
More...
P0C879
Putative uncharacterized protein FLJ43185
DEG_SPOP_SBC_1
53:57
PFSSS
SPOP
0.9272
More...