DegronMD - Q3SXY7(LRIT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A473T	TCGA-05-4382	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1667
p.G458E	TCGA-05-4397	LUAD	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1944
p.F415S	TCGA-23-1116	OV	TCGA	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6871
p.A455E	TCGA-27-1838	GBM	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.1111
p.K456Q	TCGA-63-7022	LUSC	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation substituting flanking lysine	0.25
p.S421Y	TCGA-AG-A002	READ	TCGA	VSSTT	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.6009
p.S465N	TCGA-AP-A1DV	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7069
p.S411F	TCGA-BI-A0VS	CESC	TCGA	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.25
p.S411F	TCGA-BI-A0VS	CESC	TCGA	VSSTT	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.0833
p.S417F	TCGA-E7-A541	BLCA	TCGA	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7982
p.K456N	TCGA-EO-A22R	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation substituting flanking lysine	0.25
p.P404T	TCGA-FW-A3TU	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.0556
p.T466I	TCGA-VQ-A8P2	STAD	TCGA	PASTS	DEG_SPOP_SBC_1	463:467	Mutation altering degron motif	0.7078
p.E469D	DO222762	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.E469D	DO222884	COCA	ICGC	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.E469D	DO219773	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.E469D	SNU-81	large intestine	COSMIC	PASTS	DEG_SPOP_SBC_1	463:467	Mutation rewiring degron network	0.2778
p.W434L	DO14196	HNSC	ICGC	VSSTT	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.0556
p.W434L	DO50278	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.0556
p.E431G	DO26716	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1389
p.I416S	DO46657	PAAD	ICGC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7341
p.C417S	DO36245	PRAD	ICGC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.7541
p.L415F	DO219773	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation altering degron motif	0.6981
p.S409F	SIDM00690	Head and Neck Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.S409F	SIDM01147	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.S409F	SIDM00793	Burkitt's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944
p.S409F	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	414:418	Mutation rewiring degron network	0.1944

Kaplan plot for LRIT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRIT3

UniProt ID: Q3SXY7

Entrez ID: 345193

Protein name: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRIT3 in