DegronMD

Uniprot ID: Q3SXY7

Source protein: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3

Source gene: LRIT3

Class: DEG_SPOP_SBC_1

Location: 420:424

E3 ligase: SPOP

DEGRON score: 0.9437

ASA_SCORE: 75.6

COIL: 0.85

CONS_SCORE: 0.3981

DSS_SCORE: 0.2941

HELIX: 0.0618

FCONS_SCORE: 1.1934

RIG_SCORE: 0.6675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S421Y	TCGA-AG-A002	READ	TCGA	VSSTT	DEG_SPOP_SBC_1	0.6009
p.S411F	TCGA-BI-A0VS	CESC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.0833
p.W434L	DO14196	HNSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.W434L	DO50278	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.E431G	DO26716	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons