DegronMD

Uniprot ID: Q15398

Source protein: Disks large-associated protein 5

Source gene: DLGAP5

Class: DEG_SPOP_SBC_1

Location: 220:224

E3 ligase: SPOP

DEGRON score: 0.781

ASA_SCORE: 83.52

COIL: 0.8742

CONS_SCORE: 0.276

DSS_SCORE: 0.6694

HELIX: 0.0568

FCONS_SCORE: 0.8376

RIG_SCORE: 0.671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S222F	TCGA-EE-A29V	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	0.7982
p.S222F	DO38006	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7982
p.A225S	TCGA-MA-AA3W	CESC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.3056
p.A225S	DO219719	CESC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.3056
p.T223S	TCGA-O2-A52N	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.6005
p.T223S	DO219217	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6005
p.P217T	DO223531	CLLE	ICGC	VSSTT	DEG_SPOP_SBC_1	0.25
p.T230K	DO229038	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1667
p.R218K	DO52666	MALY	ICGC	VSSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons