DegronMD - Q8TF66(LRRC15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S516N	TCGA-CQ-5333	HNSC	TCGA	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.S516N	DO14218	HNSC	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.Y496C	TCGA-D1-A103	UCEC	TCGA	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1667
p.Y496C	DO42312	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1667
p.W495L	TCGA-D3-A1Q1	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1389
p.W495L	DO37445	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1389
p.P497L	TCGA-EE-A29D	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.P497L	DO38123	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T515I	TCGA-FS-A1ZA	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.T515I	DO37551	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0833
p.S509C	DO225046	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.25
p.S510Y	DO233876	GACA	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2222
p.S516R	DO229034	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.T511I	SIDM00435	Acute Myeloid Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM01034	B-Lymphoblastic Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM00589	Oral Cavity Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM00596	Endometrial Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM00279	Gastric Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM00531	Pancreatic Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM01498	Acute Myeloid Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.T511I	SIDM01774	Pancreatic Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1944
p.D498G	SIDM01045	Endometrial Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2222
p.D498G	EN	endometrium	COSMIC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.2222
p.D492G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.D492G	EN	endometrium	COSMIC	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.0556
p.V512A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	502:506	Mutation rewiring degron network	0.1667

Kaplan plot for LRRC15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC15

UniProt ID: Q8TF66

Entrez ID: 131578

Protein name: Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC15 in