DegronMD

Uniprot ID: Q8TF66

Source protein: Leucine-rich repeat-containing protein 15

Source gene: LRRC15

Class: DEG_SPOP_SBC_1

Location: 502:506

E3 ligase: SPOP

DEGRON score: 0.584

ASA_SCORE: 85.16

COIL: 0.8978

CONS_SCORE: 0.6081

DSS_SCORE: 0.5826

HELIX: 0.0352

FCONS_SCORE: 1.0827

RIG_SCORE: 0.6912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S516N	TCGA-CQ-5333	HNSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.0556
p.S516N	DO14218	HNSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.Y496C	TCGA-D1-A103	UCEC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1667
p.Y496C	DO42312	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1667
p.W495L	TCGA-D3-A1Q1	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1389
p.W495L	DO37445	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1389
p.P497L	TCGA-EE-A29D	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	0.1944
p.P497L	DO38123	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T515I	TCGA-FS-A1ZA	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	0.0833
p.T515I	DO37551	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0833
p.S509C	DO225046	BRCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.25
p.S510Y	DO233876	GACA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.S516R	DO229034	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.T511I	SIDM00435	Acute Myeloid Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM01034	B-Lymphoblastic Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM00589	Oral Cavity Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM00596	Endometrial Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM00279	Gastric Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM00531	Pancreatic Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM01498	Acute Myeloid Leukemia	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.T511I	SIDM01774	Pancreatic Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.1944
p.D498G	SIDM01045	Endometrial Carcinoma	GDSC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.D498G	EN	endometrium	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.D492G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.0556
p.D492G	EN	endometrium	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.0556
p.V512A	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSTT

Degron related mutations and impact score

Drug responses associated with LRRC15 mutations

All proteins holding degron of VSSTT