DegronMD

Uniprot ID: O14974

Source protein: Protein phosphatase 1 regulatory subunit 12A

Source gene: PPP1R12A

Class: DEG_SPOP_SBC_1

Location: 656:660

E3 ligase: SPOP

DEGRON score: 0.9967

ASA_SCORE: 76.56

COIL: 0.793

CONS_SCORE: 0.2955

DSS_SCORE: 0.5914

HELIX: 0.1222

FCONS_SCORE: 0.8291

RIG_SCORE: 0.7428

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S657F	TCGA-77-A5G3	LUSC	TCGA	VSSTT	DEG_SPOP_SBC_1	0.6871
p.S657F	TCGA-DK-AA6U	BLCA	TCGA	VSSTT	DEG_SPOP_SBC_1	0.6871
p.S657F	DO219008	BLCA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6871
p.S657F	DO45456	LUSC	ICGC	VSSTT	DEG_SPOP_SBC_1	0.6871
p.S658Y	TCGA-FS-A1ZP	SKCM	TCGA	VSSTT	DEG_SPOP_SBC_1	0.712
p.S658Y	DO37703	SKCM	ICGC	VSSTT	DEG_SPOP_SBC_1	0.712
p.T659K	DO229019	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.7306
p.T661N	DO229028	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.3056
p.T661N	DO229037	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.3056
p.T650K	DO229036	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1667
p.Q649K	DO229041	LICA	ICGC	VSSTT	DEG_SPOP_SBC_1	0.1389
p.R664T	D-423MG	central_nervous_system	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.2222
p.R659L	NCI-H2347	lung	COSMIC	VSSTT	DEG_SPOP_SBC_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	656:660	VSSTT	SPOP	0.9967	More...
Q15398	Disks large-associated protein 5	DEG_SPOP_SBC_1	220:224	VSSTT	SPOP	0.781	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	420:424	VSSTT	SPOP	0.9437	More...
Q8NHH9	Atlastin-2	DEG_SPOP_SBC_1	33:37	VSSTT	SPOP	0.999	More...
Q8TBY9	Cilia- and flagella-associated protein 251	DEG_SPOP_SBC_1	229:233	VSSTT	SPOP	0.9658	More...
Q8TC05	Nuclear protein MDM1	DEG_SPOP_SBC_1	373:377	VSSTT	SPOP	0.9916	More...
Q8TF66	Leucine-rich repeat-containing protein 15	DEG_SPOP_SBC_1	502:506	VSSTT	SPOP	0.584	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1165:1169	VSSTT	SPOP	0.9972	More...
Q96K83	Zinc finger protein 521	DEG_SPOP_SBC_1	354:358	VSSTT	SPOP	0.9025	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	845:849	VSSTT	SPOP	0.9657	More...
A6NMB9	Fidgetin-like protein 2	DEG_SPOP_SBC_1	21:25	VSSTT	SPOP	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons