DegronMD - Q96HA1(POM121)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F799I	TCGA-20-0991	OV	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.3056
p.F799I	DO31949	OV	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.3056
p.T769M	TCGA-21-1076	LUSC	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2222
p.T769M	DO26599	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2222
p.H762Q	TCGA-29-1763	OV	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	DO231075	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	DO28422	OV	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00557	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00266	Ewing's Sarcoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00690	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00489	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00815	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00254	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00875	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00793	Burkitt's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00720	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.H762Q	SIDM00168	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7582
p.G809R	TCGA-3N-A9WC	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1944
p.G809R	DO51234	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1944
p.P747L	TCGA-3N-A9WD	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.P747L	SIDM01451	Pancreatic Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.P747L	ACH-000933	Pancreatic Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.P747L	ACH-001035	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.A861D	TCGA-A5-A0G1	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.0833
p.G767S	TCGA-AA-3672	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0833
p.G767S	TCGA-AA-3672	COAD	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2778
p.G767S	DO9010	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0833
p.G767S	DO9010	COAD	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2778
p.G767S	J82	urinary tract	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0833
p.G767S	J82	urinary tract	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2778
p.P916A	TCGA-AC-A5EI	BRCA	TCGA	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.P916A	DO223932	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2778
p.G766D	TCGA-AJ-A3EK	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1111
p.G766D	TCGA-AJ-A3EK	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.3056
p.G766D	DO41584	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1111
p.G766D	DO41584	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.3056
p.P790S	TCGA-AO-A128	BRCA	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.0556
p.P790S	DO5326	BRCA	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.0556
p.T922I	TCGA-AP-A059	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1111
p.T922I	TCGA-AP-A059	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1111
p.T922I	DO41361	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1111
p.T922I	DO41361	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1111
p.T804I	TCGA-AP-A1DK	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation altering degron motif	0.7078
p.T804I	DO42033	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation altering degron motif	0.7078
p.A489V	TCGA-AX-A1C5	UCEC	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.A489V	TCGA-B5-A0K9	UCEC	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.A489V	DO42097	UCEC	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.A489V	DO41422	UCEC	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.S771L	TCGA-AX-A2HA	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1667
p.S771L	TCGA-BA-6871	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1667
p.S771L	DO15254	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1667
p.S771L	DO42504	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1667
p.S806C	TCGA-B5-A11R	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.2778
p.S806C	DO43787	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.2778
p.P763A	TCGA-B8-5164	KIRC	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7503
p.P763A	DO17018	KIRC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7503
p.P923H	TCGA-BR-4256	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.0833
p.P923H	TCGA-BR-4256	STAD	TCGA	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1389
p.T421M	TCGA-BR-4368	STAD	TCGA	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1944
p.T488I	TCGA-CK-4951	COAD	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation altering degron motif	0.7078
p.T488I	DO10582	COAD	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation altering degron motif	0.7078
p.S771W	TCGA-CV-A45Q	HNSC	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1667
p.S771W	DO49060	HNSC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1667
p.G911R	TCGA-D1-A160	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7568
p.M749V	TCGA-DD-AADG	LIHC	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.M749V	DO219571	LIHC	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.G911A	TCGA-DK-A3X1	BLCA	TCGA	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.754
p.G911A	DO447	BLCA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.754
p.A408V	TCGA-DU-6392	LGG	TCGA	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2222
p.F808C	TCGA-DX-A6YS	SARC	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.2222
p.F808C	DO220005	SARC	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.2222
p.E905K	TCGA-E2-A10C	BRCA	TCGA	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1944
p.E905K	DO1334	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1944
p.S404F	TCGA-EE-A29D	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1111
p.S404F	DO38123	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1111
p.T857I	TCGA-EE-A2MD	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation rewiring degron network	0.0556
p.T857I	TCGA-EE-A2MD	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.1944
p.T857I	DO37851	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation rewiring degron network	0.0556
p.T857I	DO37851	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.1944
p.T814I	TCGA-EE-A2MI	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.0556
p.T814I	DO37531	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.0556
p.P480L	TCGA-EE-A3AC	SKCM	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.P480L	SIDM00826	Colorectal Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.P480L	SIDM00823	Colorectal Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.3056
p.A755V	TCGA-EO-A22R	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6936
p.A755V	DO42713	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6936
p.A755V	ACH-002134	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6936
p.A755V	H2818	pleura	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6936
p.A755V	ChaGo-K-1	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6936
p.A755V	Hs-445	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6936
p.N849S	TCGA-H4-A2HQ	BLCA	TCGA	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation altering degron motif	0.7069
p.N849S	DO522	BLCA	ICGC	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation altering degron motif	0.7069
p.A487T	TCGA-IB-7651	PAAD	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation altering degron motif	0.7139
p.A487T	DO46657	PAAD	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation altering degron motif	0.7139
p.S404C	TCGA-IR-A3LH	CESC	TCGA	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1111
p.S404C	DO44381	CESC	ICGC	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1111
p.S795Y	TCGA-L9-A7SV	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1944
p.S795Y	DO49875	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1944
p.T833M	TCGA-QK-A6VB	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation substituting flanking lysine	0.1667
p.T833M	TCGA-XF-AAN3	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation substituting flanking lysine	0.1667
p.T833M	DO219053	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation substituting flanking lysine	0.1667
p.T833M	DO219054	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation substituting flanking lysine	0.1667
p.V757L	TCGA-QL-A97D	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6765
p.V757L	DO51732	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.6765
p.V753M	TCGA-WS-AB45	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.3056
p.V753M	TCGA-WS-AB45	COAD	TCGA	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1111
p.V753M	DO51734	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.3056
p.V753M	DO51734	COAD	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.1111
p.E474Q	TCGA-ZF-AA51	BLCA	TCGA	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.1389
p.E474Q	DO219093	BLCA	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.1389
p.Y756H	DO48451	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO222590	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO222748	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO222729	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO229010	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO229013	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO229016	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO229003	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO229005	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	DO218848	SKCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.Y756H	SIDM01761	Rhabdomyosarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7229
p.H904P	DO228783	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1667
p.H904P	DO228941	LICA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1667
p.T909M	DO52087	HNSC	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.3056
p.A861S	DO50957	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.0833
p.A861V	DO50957	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.0833
p.S902C	DO25153	LUAD	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1111
p.A570V	DO52365	LUSC	ICGC	VTETPPIT	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.3056
p.I764T	DO231075	LUSC	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00690	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00489	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00254	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00875	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00793	Burkitt's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00720	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	SIDM00168	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	NCI-H28	pleura	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	NCI-H250	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	HCC1806	breast	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	Ca9-22	upper aerodigestive tract	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	JHU-029	upper aerodigestive tract	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	ZR-75-30	breast	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.I764T	HCC-15	lung	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation altering degron motif	0.7078
p.A803V	DO222731	MELA	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation altering degron motif	0.6936
p.P747A	DO27911	ORCA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.P747A	JHU-029	upper aerodigestive tract	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.P747A	Daudi	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.A768D	DO33208	PACA	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0556
p.A768D	DO33208	PACA	ICGC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.25
p.S906N	DO232761	PBCA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.2222
p.I575V	DO232681	PBCA	ICGC	VTETPPIT	DEG_SCF_FBW7_1	562:569	Mutation rewiring degron network	0.1667
p.P498L	DO219335	PRAD	ICGC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.0556
p.P745L	DO37631	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0833
p.S902F	DO47601	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.1111
p.A914T	DO229208	THCA	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7139
p.A914T	ACH-001610	Brain Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7139
p.G928D	DO229240	THCA	ICGC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.2778
p.A810G	DO229250	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1667
p.G1176R	DO41626	UCEC	ICGC	VSSTT	DEG_SPOP_SBC_1	1165:1169	Mutation rewiring degron network	0.1389
p.V907M	DO43755	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.25
p.V907M	RL95-2	endometrium	COSMIC	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.25
p.A1126D	DO42472	UCEC	ICGC	VATPGSS	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.1944
p.A1126D	DO42472	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	1118:1122	Mutation rewiring degron network	0.2222
p.P936S	DO41361	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.2778
p.P936S	ACH-000997	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.2778
p.T769A	SIDM00680	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2222
p.T769A	ACH-000957	Colon/Colorectal Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2222
p.T769A	LS-180	large intestine	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.2222
p.T857A	SIDM00961	Ewing's Sarcoma	GDSC	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation rewiring degron network	0.0556
p.T857A	SIDM00961	Ewing's Sarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.1944
p.P481L	SIDM01114	Non-Cancerous	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation altering degron motif	0.7582
p.S939F	SIDM00587	Biliary Tract Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1944
p.S939F	ACH-000976	Bile Duct Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1944
p.S939F	HuCCT1	biliary tract	COSMIC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1944
p.P760L	SIDM00140	Melanoma	GDSC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2778
p.P760L	SIDM00140	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.3056
p.P760L	ACH-000968	Skin Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2778
p.P760L	ACH-000968	Skin Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.3056
p.P760L	COLO-792	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2778
p.P760L	COLO-792	skin	COSMIC	PTTTS	DEG_SPOP_SBC_1	761:765	Mutation rewiring degron network	0.3056
p.E474K	SIDM00528	Breast Carcinoma	GDSC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.1389
p.E474K	MDA-MB-361	breast	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.1389
p.T929P	SIDM00257	Neuroblastoma	GDSC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.3056
p.T929P	ACH-002280	Neuroblastoma	CCLE	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.3056
p.S901G	ACH-000291	Ovarian Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.0833
p.Q793E	ACH-000427	Gastric Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1389
p.Q793E	ACH-000515	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1389
p.Q793E	ACH-000612	Lymphoma	CCLE	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1389
p.Q793E	ACH-000621	Breast Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	800:804	Mutation rewiring degron network	0.1389
p.P744L	ACH-000439	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0556
p.P744L	ME-1	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0556
p.P744L	DJM-1	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0556
p.P840L	ACH-000822	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation rewiring degron network	0.25
p.P840L	ACH-000822	Skin Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.1111
p.P840L	SK-MEL-24	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation rewiring degron network	0.25
p.P840L	SK-MEL-24	skin	COSMIC	VSTTT	DEG_SPOP_SBC_1	848:852	Mutation rewiring degron network	0.1111
p.G1066S	ACH-000870	Lung Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	1067:1071	Mutation rewiring degron network	0.3056
p.T420A	ACH-000919	Gastric Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2222
p.T420A	IM-95	stomach	COSMIC	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.2222
p.T924N	ACH-000941	Endometrial/Uterine Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.0556
p.T924N	ACH-000941	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1667
p.T924N	ACH-000954	Endometrial/Uterine Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation rewiring degron network	0.0556
p.T924N	ACH-000954	Endometrial/Uterine Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1667
p.K792N	ACH-000977	lymph node	CCLE	APTTT	DEG_SPOP_SBC_1	800:804	Mutation substituting flanking lysine	0.2222
p.S847N	ACH-000985	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	843:847	Mutation altering degron motif	0.7069
p.S913N	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	910:914	Mutation altering degron motif	0.7069
p.M749T	Daudi	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.M749T	JHU-029	upper aerodigestive tract	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.M749T	OE19	oesophagus	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.P478L	RXF393	kidney	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	IPC-298	skin	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	MPP-89	pleura	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	LCLC-103H	lung	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	G-MEL	skin	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	CAL-29	urinary tract	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	NCI-H1105	lung	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	NCI-H720	lung	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	NCI-H716	large intestine	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	RS4-11	haematopoietic and lymphoid tissue	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P478L	SU-DHL-8	NS	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.25
p.P415T	SW962	vulva	COSMIC	AITSS	DEG_SPOP_SBC_1	412:416	Mutation altering degron motif	0.7031
p.A1067S	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	1067:1071	Mutation altering degron motif	0.7588
p.T943M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.0833
p.A802S	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	800:804	Mutation altering degron motif	0.7588
p.V757M	GI-ME-N	autonomic ganglia	COSMIC	APSSS	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7208
p.A472V	SW156	kidney	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.0833
p.A472V	SNU-1040	large intestine	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.0833
p.P407S	KP-N-YN	autonomic ganglia	COSMIC	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.1944
p.S941G	T-T	oesophagus	COSMIC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1389
p.Q425H	WM1552C	skin	COSMIC	AITSS	DEG_SPOP_SBC_1	412:416	Mutation rewiring degron network	0.0833
p.R474K	NCI-H1417	lung	COSMIC	AADTTPRK	DEG_SCF_SKP2-CKS1_1	481:488	Mutation rewiring degron network	0.1389
p.T939M	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.1944
p.P1105L	SK-MEL-24	skin	COSMIC	VATPGSS	DEG_SCF_FBW7_1	1115:1121	Mutation rewiring degron network	0.0556
p.A929T	C-33-A	cervix	COSMIC	PATSS	DEG_SPOP_SBC_1	930:934	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POM121

UniProt ID: Q96HA1

Entrez ID: 9883

Protein name: Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for POM121 in