DegronMD

Uniprot ID: Q96HA1

Source protein: Nuclear envelope pore membrane protein POM 121

Source gene: POM121

Class: DEG_SPOP_SBC_1

Location: 412:416

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 66.38

COIL: 0.8164

CONS_SCORE: 0.8516

DSS_SCORE: 0.4979

HELIX: 0.0268

FCONS_SCORE: 1.1149

RIG_SCORE: 0.6918

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T421M	TCGA-BR-4368	STAD	TCGA	AITSS	DEG_SPOP_SBC_1	0.1944
p.A408V	TCGA-DU-6392	LGG	TCGA	AITSS	DEG_SPOP_SBC_1	0.2222
p.S404F	TCGA-EE-A29D	SKCM	TCGA	AITSS	DEG_SPOP_SBC_1	0.1111
p.S404F	DO38123	SKCM	ICGC	AITSS	DEG_SPOP_SBC_1	0.1111
p.S404C	TCGA-IR-A3LH	CESC	TCGA	AITSS	DEG_SPOP_SBC_1	0.1111
p.S404C	DO44381	CESC	ICGC	AITSS	DEG_SPOP_SBC_1	0.1111
p.T420A	ACH-000919	Gastric Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	0.2222
p.T420A	IM-95	stomach	COSMIC	AITSS	DEG_SPOP_SBC_1	0.2222
p.P415T	SW962	vulva	COSMIC	AITSS	DEG_SPOP_SBC_1	0.7031
p.P407S	KP-N-YN	autonomic_ganglia	COSMIC	AITSS	DEG_SPOP_SBC_1	0.1944
p.Q425H	WM1552C	skin	COSMIC	AITSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	389:393	AITSS	SPOP	0.9987	More...
Q5RL73	RNA-binding protein 48	DEG_SPOP_SBC_1	264:268	AITSS	SPOP	0.6026	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	639:643	AITSS	SPOP	0.9699	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	412:416	AITSS	SPOP	0.9984	More...
Q9Y2F5	Little elongation complex subunit 1	DEG_SPOP_SBC_1	236:240	AITSS	SPOP	0.9901	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	145:149	AITSS	SPOP	0.9606	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons