DegronMD - Q8N1G0(ZNF687)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1095L	TCGA-37-5819	LUSC	TCGA	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.3056
p.Q869R	TCGA-A2-A0YM	BRCA	TCGA	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.3056
p.Q869R	DO1842	BRCA	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.3056
p.T1093M	TCGA-A5-A1OF	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation altering degron motif	0.7423
p.R1080C	TCGA-AP-A1DK	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.0556
p.K333T	TCGA-AX-A05Z	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	320:324	Mutation substituting flanking lysine	0.1944
p.K333T	DO40884	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	320:324	Mutation substituting flanking lysine	0.1944
p.S387N	TCGA-AX-A1CE	UCEC	TCGA	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1667
p.S387N	DO42280	UCEC	ICGC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1667
p.P631S	TCGA-BH-A18G	BRCA	TCGA	AITSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1111
p.P631S	TCGA-RW-A8AZ	PCPG	TCGA	AITSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1111
p.P631S	DO3686	BRCA	ICGC	AITSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1111
p.V386L	TCGA-CG-5721	STAD	TCGA	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1944
p.V386L	DO38192	STAD	ICGC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1944
p.Q389H	TCGA-EO-A22U	UCEC	TCGA	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1111
p.Q389H	DO43755	UCEC	ICGC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1111
p.H876R	TCGA-FS-A1ZK	SKCM	TCGA	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation altering degron motif	0.7133
p.H876R	DO37474	SKCM	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation altering degron motif	0.7133
p.P320T	TCGA-G2-A2EJ	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7031
p.P320T	DO554	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7031
p.R1101K	TCGA-IB-7651	PAAD	TCGA	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.1389
p.S325Y	TCGA-P3-A6T5	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.S325Y	DO49066	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.T1099M	DO219743	CESC	ICGC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation blocking phosphorylation signal	0.6389
p.E887D	DO230323	COCA	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.0833
p.S643Y	DO222874	COCA	ICGC	AITSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.712
p.A629S	DO229015	LICA	ICGC	AITSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.0556
p.S1092I	DO229022	LICA	ICGC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation altering degron motif	0.7341
p.E381K	DO230529	LUSC	ICGC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation altering degron motif	0.7022
p.E381K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation altering degron motif	0.7022
p.E381K	ACH-000951	Lung Cancer	CCLE	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation altering degron motif	0.7022
p.E381K	NCI-H2342	lung	COSMIC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation altering degron motif	0.7022
p.P1080S	DO220911	MELA	ICGC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.0556
p.R885L	DO222423	MELA	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.1389
p.R885L	DO37425	SKCM	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.1389
p.A376V	DO232761	PBCA	ICGC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation altering degron motif	0.5825
p.R1096K	DO36556	READ	ICGC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.2778
p.P1100L	DO42033	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.1667
p.R1080H	SIDM01307	Colorectal Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.0556
p.E1089D	SIDM01951	Colorectal Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	1090:1094	Mutation rewiring degron network	0.3056
p.A368T	SIDM00216	Colorectal Carcinoma	GDSC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1389
p.A368T	ACH-000989	Colon/Colorectal Cancer	CCLE	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.1389
p.R885H	SIDM00463	T-Lymphoblastic Leukemia	GDSC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.1389
p.R885H	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	KRTMLEHLK	DEG_APCC_DBOX_1	870:878	Mutation rewiring degron network	0.1389
p.A894V	SIDM00310	Mesothelioma	GDSC	LLTPKTE	DEG_SCF_FBW7_2	898:904	Mutation rewiring degron network	0.2222
p.A650T	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AITSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1389
p.P383A	SIDM00191	Kidney Carcinoma	GDSC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.2778
p.P383A	ACH-002090	Kidney Cancer	CCLE	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.2778
p.P383A	BB65-RCC	kidney	COSMIC	PATPTSE	DEG_SCF_FBW7_2	375:381	Mutation rewiring degron network	0.2778
p.T641P	ACH-001331	Head and Neck Cancer	CCLE	AITSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF687

UniProt ID: Q8N1G0

Entrez ID: 57592

Protein name: Zinc finger protein 687

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF687 in