DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LLTPKTE
Uniprot ID:
Q8N1G0
Source protein:
Zinc finger protein 687
Source gene:
ZNF687
Class:
DEG_SCF_FBW7_2
Location:
898:904
E3 ligase:
FBXW7
DEGRON score:
0.9944
ASA_SCORE:
84.0571
COIL:
0.8036
CONS_SCORE:
0.3916
DSS_SCORE:
0.6849
HELIX:
0.0487
FCONS_SCORE:
1.1134
RIG_SCORE:
0.6928
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A894V
SIDM00310
Mesothelioma
GDSC
LLTPKTE
DEG_SCF_FBW7_2
0.2222
Drug responses associated with ZNF687 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLTPKTE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N1G0
Zinc finger protein 687
DEG_SCF_FBW7_2
898:904
LLTPKTE
FBXW7
0.9944
More...