DegronMD

Uniprot ID: Q8N1G0

Source protein: Zinc finger protein 687

Source gene: ZNF687

Class: DEG_SPOP_SBC_1

Location: 1090:1094

E3 ligase: SPOP

DEGRON score: 0.9434

ASA_SCORE: 78.54

COIL: 0.905

CONS_SCORE: 0.3329

DSS_SCORE: 0.8094

HELIX: 0.0224

FCONS_SCORE: 0.8852

RIG_SCORE: 0.5204

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1095L	TCGA-37-5819	LUSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.T1093M	TCGA-A5-A1OF	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.R1080C	TCGA-AP-A1DK	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0556
p.R1101K	TCGA-IB-7651	PAAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1389
p.T1099M	DO219743	CESC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.6389
p.S1092I	DO229022	LICA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7341
p.P1080S	DO220911	MELA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.0556
p.R1096K	DO36556	READ	ICGC	PDSTT	DEG_SPOP_SBC_1	0.2778
p.P1100L	DO42033	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.R1080H	SIDM01307	Colorectal Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.0556
p.E1089D	SIDM01951	Colorectal Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons