DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 930:934

E3 ligase: SPOP

DEGRON score: 0.6761

ASA_SCORE: 87.54

COIL: 0.8476

CONS_SCORE: 0.5236

DSS_SCORE: 0.7109

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.6434

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T934M	TCGA-BK-A6W3	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	TCGA-EO-A3AZ	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	TCGA-NH-A5IV	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	DO49095	COAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	DO50076	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	DO50078	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7423
p.D931H	TCGA-18-3416	LUSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.6577
p.D931H	DO26423	LUSC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.6577
p.D931N	TCGA-BR-A4QI	STAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D931N	DO38523	STAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.5821
p.T943K	ACH-001321	Thyroid Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.5278
p.T943K	TT	thyroid	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.5278
p.P935S	TCGA-55-8089	LUAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935S	TCGA-D9-A6EC	SKCM	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935S	DO23690	LUAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935S	DO50291	SKCM	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	TCGA-AX-A2HC	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	TCGA-CV-7245	HNSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	DO14322	HNSC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	DO41572	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00454	Rhabdomyosarcoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00928	Breast Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00814	Other Solid Cancers	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00943	Pancreatic Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons