DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 930:934

E3 ligase: SPOP

DEGRON score: 0.6761

ASA_SCORE: 87.54

COIL: 0.8476

CONS_SCORE: 0.5236

DSS_SCORE: 0.7109

HELIX: 0.0136

FCONS_SCORE: 1

RIG_SCORE: 0.6434

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D931H	TCGA-18-3416	LUSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.6577
p.D931H	DO26423	LUSC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.6577
p.R942T	TCGA-49-4494	LUAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1111
p.R942T	TCGA-NK-A7XE	LUSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1111
p.R942T	DO24245	LUAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1111
p.R942T	DO219215	LUSC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1111
p.P935S	TCGA-55-8089	LUAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935S	TCGA-D9-A6EC	SKCM	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935S	DO23690	LUAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935S	DO50291	SKCM	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.G922R	TCGA-AA-3980	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1111
p.G922R	DO8455	COAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1111
p.V936I	TCGA-AP-A0LM	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.2778
p.V936I	DO43306	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.2778
p.P935T	TCGA-AX-A2HC	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	TCGA-CV-7245	HNSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	DO14322	HNSC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935T	DO41572	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.T934M	TCGA-BK-A6W3	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	TCGA-EO-A3AZ	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	TCGA-NH-A5IV	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	DO49095	COAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	DO50076	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7423
p.T934M	DO50078	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7423
p.D931N	TCGA-BR-A4QI	STAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D931N	DO38523	STAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.5821
p.E940Q	TCGA-C8-A12T	BRCA	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1667
p.E940Q	DO5507	BRCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.V937L	TCGA-L5-A4OJ	ESCA	TCGA	PDSTT	DEG_SPOP_SBC_1	0.25
p.E940V	DO227976	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.G920R	DO222519	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.0556
p.G920R	DO229013	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.0556
p.G920R	DO229016	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.0556
p.A941V	DO222849	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.A941V	DO229013	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.A941V	DO229016	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.R942S	DO229013	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1111
p.R942S	DO229016	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1111
p.R942S	DO52365	LUSC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1111
p.E940G	DO229013	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.E940G	DO229016	COCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.S928G	DO234281	ESAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.2778
p.P935L	SIDM00454	Rhabdomyosarcoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00928	Breast Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00814	Other Solid Cancers	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00943	Pancreatic Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM00808	Burkitt's Lymphoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.P935L	SIDM01254	Burkitt's Lymphoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.3056
p.V937I	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.25
p.V937I	ACH-000853	Lung Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.25
p.V937I	NCI-H661	lung	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.25
p.A941D	SIDM00148	Breast Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.A941D	MCF7	breast	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.P925R	SIDM00032	Bladder Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.1944
p.L926F	SIDM00032	Bladder Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.2222
p.T943K	ACH-001321	Thyroid Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.5278
p.T943K	TT	thyroid	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	930:934	PDSTT	SPOP	0.6761	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	1090:1094	PDSTT	SPOP	0.9434	More...
Q9BS16	Centromere protein K	DEG_SPOP_SBC_1	8:12	PDSTT	SPOP	0.7648	More...
Q9NRE2	Teashirt homolog 2	DEG_SPOP_SBC_1	333:337	PDSTT	SPOP	0.836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSTT

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PDSTT