DegronMD

Uniprot ID: Q9BS16

Source protein: Centromere protein K

Source gene: CENPK

Class: DEG_SPOP_SBC_1

Location: 8:12

E3 ligase: SPOP

DEGRON score: 0.7648

ASA_SCORE: 80.2

COIL: 0.9338

CONS_SCORE: 0.3468

DSS_SCORE: 0.784

HELIX: 0.058

FCONS_SCORE: 0.972

RIG_SCORE: 0.6631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D9Y	TCGA-44-7670	LUAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.6214
p.D9Y	DO23555	LUAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.6214
p.E22G	TCGA-AA-3845	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0556
p.E22G	DO10020	COAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.0556
p.P8S	TCGA-EO-A22U	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.6752
p.P8S	DO43755	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.6752
p.D5N	SIDM01045	Endometrial Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.25
p.D5N	ACH-000978	Endometrial/Uterine Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.25
p.D5N	EN	endometrium	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.25
p.I15T	EFO-21	ovary	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.25
p.E7K	SNU-81	large_intestine	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons