DegronMD

Uniprot ID: Q9NRE2

Source protein: Teashirt homolog 2

Source gene: TSHZ2

Class: DEG_SPOP_SBC_1

Location: 333:337

E3 ligase: SPOP

DEGRON score: 0.836

ASA_SCORE: 87.54

COIL: 0.9148

CONS_SCORE: 0.4627

DSS_SCORE: 0.4462

HELIX: 0.0612

FCONS_SCORE: 0.9792

RIG_SCORE: 0.653

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G338V	TCGA-19-5956	GBM	TCGA	PDSTT	DEG_SPOP_SBC_1	0.3056
p.V324F	TCGA-34-5929	LUSC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0833
p.V324F	DO229006	LICA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.0833
p.R323L	TCGA-38-4631	LUAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0556
p.V324I	TCGA-76-6192	GBM	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0833
p.V324I	TCGA-DC-4749	READ	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0833
p.V324I	SIDM00629	Breast Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.0833
p.V324I	ACH-000573	Breast Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.0833
p.R329L	TCGA-CG-5721	STAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.2222
p.R329Q	TCGA-CK-4952	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.2222
p.R329Q	TCGA-CK-6746	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.2222
p.R329Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PDSTT	DEG_SPOP_SBC_1	0.2222
p.R329Q	ACH-000918	Leukemia	CCLE	PDSTT	DEG_SPOP_SBC_1	0.2222
p.R329Q	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.2222
p.S345Y	TCGA-DF-A2KV	UCEC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1111
p.S343Y	TCGA-FU-A3HZ	CESC	TCGA	PDSTT	DEG_SPOP_SBC_1	0.1667
p.R323H	TCGA-QG-A5Z2	COAD	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0556
p.P330L	TCGA-W3-AA1V	SKCM	TCGA	PDSTT	DEG_SPOP_SBC_1	0.25
p.Q347E	TCGA-XF-A9ST	BLCA	TCGA	PDSTT	DEG_SPOP_SBC_1	0.0556
p.Q344E	DO223599	BLCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.R326Q	DO225365	BRCA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.R326Q	DO10357	COAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.R326Q	DO7938	COAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.R326Q	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.S340Y	DO6308	CESC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.25
p.D331N	DO234360	ESAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.2778
p.D331N	CL-34	large_intestine	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.2778
p.D331N	SW48	large_intestine	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.2778
p.R326W	DO233163	GACA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.G335V	DO13863	GBM	ICGC	PDSTT	DEG_SPOP_SBC_1	0.7532
p.P327S	DO220873	MELA	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.P327L	DO51276	SKCM	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1667
p.R326L	DO38192	STAD	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1389
p.S342Y	DO219771	UCEC	ICGC	PDSTT	DEG_SPOP_SBC_1	0.1944
p.P330A	SIDM00578	Neuroblastoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.25
p.P330A	ACH-000804	Neuroblastoma	CCLE	PDSTT	DEG_SPOP_SBC_1	0.25
p.D334N	SIDM00945	Colorectal Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D334N	SIDM00837	Colorectal Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D334N	ACH-000895	Colon/Colorectal Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D334N	ACH-000958	Colon/Colorectal Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D334N	SW48	large_intestine	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.5821
p.D334N	CL-34	large_intestine	COSMIC	PDSTT	DEG_SPOP_SBC_1	0.5821
p.S335L	SIDM01735	Biliary Tract Carcinoma	GDSC	PDSTT	DEG_SPOP_SBC_1	0.7667
p.S335L	ACH-000808	Bile Duct Cancer	CCLE	PDSTT	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	930:934	PDSTT	SPOP	0.6761	More...
Q8N1G0	Zinc finger protein 687	DEG_SPOP_SBC_1	1090:1094	PDSTT	SPOP	0.9434	More...
Q9BS16	Centromere protein K	DEG_SPOP_SBC_1	8:12	PDSTT	SPOP	0.7648	More...
Q9NRE2	Teashirt homolog 2	DEG_SPOP_SBC_1	333:337	PDSTT	SPOP	0.836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSTT

Degron related mutations and impact score

Drug responses associated with TSHZ2 mutations

All proteins holding degron of PDSTT