DegronMD

Uniprot ID: Q8N1G0

Source protein: Zinc finger protein 687

Source gene: ZNF687

Class: DEG_APCC_DBOX_1

Location: 870:878

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7359

ASA_SCORE: 82.7444

COIL: 0.2721

CONS_SCORE: 0.5718

DSS_SCORE: 0.3474

HELIX: 0.7099

FCONS_SCORE: 1.1108

RIG_SCORE: 0.7929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q869R	TCGA-A2-A0YM	BRCA	TCGA	KRTMLEHLK	DEG_APCC_DBOX_1	0.3056
p.Q869R	DO1842	BRCA	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	0.3056
p.H876R	TCGA-FS-A1ZK	SKCM	TCGA	KRTMLEHLK	DEG_APCC_DBOX_1	0.7133
p.H876R	DO37474	SKCM	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	0.7133
p.E887D	DO230323	COCA	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	0.0833
p.R885L	DO222423	MELA	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	0.1389
p.R885L	DO37425	SKCM	ICGC	KRTMLEHLK	DEG_APCC_DBOX_1	0.1389
p.R885H	SIDM00463	T-Lymphoblastic Leukemia	GDSC	KRTMLEHLK	DEG_APCC_DBOX_1	0.1389
p.R885H	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	KRTMLEHLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1G0	Zinc finger protein 687	DEG_APCC_DBOX_1	870:878	KRTMLEHLK	APC,CDC20,FZR1	0.7359	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons